Significance of inhibin B and anti-Mullerian hormone in seminal plasma: a preliminary study
Significance of inhibin B and anti-Mullerian hormone in seminal plasma: a preliminary study
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DOI：
10.1016/j.fertnstert.2007.03.032
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发表时间：
2008-02-01
影响因子：
6.7
通讯作者：
Levy, Rachel
中科院分区：
文献类型：
--
作者：
Duvilla, Emma;Lejeune, Herve;Levy, Rachel
目的：评价精液中精浆白蛋白B和抗苗勒管激素（AMH）对非梗阻性无精子症患者睾丸精子提取术（TESE）结果的预测价值。设计：前瞻性研究。地点：生殖生物学部门。患者：47名正常精子患者，28名少精子症患者和68名无精子症患者。干预措施：睾丸精子提取术。主要结果指标：结果：精浆中AMH和精浆中AMB的测定值分布较广。精浆AMH和AMB B值在三组间差异有统计学意义。精液AMH（而不是AMB B）的平均比率根据无精子症的病因而有显著差异，两种精液标志物是相关的。精浆中AMH与精子数无相关性，精浆中AMH与精浆中AMH B呈显著正相关。精浆和血清白蛋白B之间也存在显著相关性。各参数对TESE结局的预测值均较低。将血清FSH、精浆内毒素B和AMH联合进行Logistic回归分析，其曲线下面积为0.985。结论：精浆内毒素B和AMH的值是合理的。另外，精液标志物是TESE结果的不良预测因子。逻辑回归模型得到令人满意的曲线下面积0.985。
Objective: To evaluate the predictive value of seminal inhibin B and anti-Mullerian hormone (AMH) on the outcome of testicular sperm extraction (TESE) in patients with nonobstructive azoospermia.Design: Prospective study.Setting: Reproductive biology department.Patient(s): Forty-seven normospermic, 28 oligozoospermic, and 68 azoospermic patients.Intervention(S): Testicular sperm extraction.Main Outcome Measure(s): Seminal inhibin B and AMH measure.Result(s): The seminal values of inhibin B and AMH are widely dispersed. Both inhibin B and AMH seminal values are significantly different between the three groups. The average rates of seminal AMH (not inhibin B) differ significantly according to the etiology of the azoospermia.Both seminal markers are correlated. A significant positive correlation could be observed between the seminal inhibin B and the sperm count, but not for AMH. A significant correlation also exists between seminal and serum inhibin B. The predictive value for TESE outcome of each parameter is rather low. Conversely, a logistic regression combining serum FSH, seminal inhibin B, and AMH produced a satisfying area under the curve of 0.985.Conclusion(s): Seminal inhibin B and AMH values are proposed. Separately, seminal markers are poor predictors of TESE outcome. A logistic regression model led to a satisfying area under the curve of 0.985.