Key Role of Human ABC Transporter ABCG2 in Photodynamic Therapy and Photodynamic Diagnosis.
Key Role of Human ABC Transporter ABCG2 in Photodynamic Therapy and Photodynamic Diagnosis.
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DOI：
10.1155/2010/587306
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发表时间：
2010
影响因子：
--
通讯作者：
Kuroiwa T
中科院分区：
文献类型：
--
作者：
Ishikawa T;Nakagawa H;Hagiya Y;Nonoguchi N;Miyatake S;Kuroiwa T
越来越多的证据表明，ATP结合盒（ABC）转运蛋白ABCG 2在调节卟啉衍生物在癌细胞中的细胞积累中起关键作用，从而影响光动力治疗和光动力诊断的功效。卟啉外排的活性可受ABCG 2基因中的遗传多态性影响。另一方面，Nrf 2，NF-E2相关的转录因子，已被证明参与氧化应激介导的ABCG 2基因的诱导。由于患者对光动力疗法的反应存在个体差异，因此癌细胞中ABCG 2基因的转录激活和/或遗传多态性可能会影响患者对光动力疗法的反应。蛋白激酶抑制剂，包括甲磺酸伊马替尼和吉非替尼，被认为可能通过阻断ABCG 2介导的卟啉从癌细胞流出来增强光动力疗法的功效。本文就人ABC转运蛋白ABCG 2在光动力学治疗和光动力学诊断中的作用作一综述。
Accumulating evidence indicates that ATP-binding cassette (ABC) transporter ABCG2 plays a key role in regulating the cellular accumulation of porphyrin derivatives in cancer cells and thereby affects the efficacy of photodynamic therapy and photodynamic diagnosis. The activity of porphyrin efflux can be affected by genetic polymorphisms in the ABCG2 gene. On the other hand, Nrf2, an NF-E2-related transcription factor, has been shown to be involved in oxidative stress-mediated induction of the ABCG2 gene. Since patients have demonstrated individual differences in their response to photodynamic therapy, transcriptional activation and/or genetic polymorphisms of the ABCG2 gene in cancer cells may affect patients' responses to photodynamic therapy. Protein kinase inhibitors, including imatinib mesylate and gefitinib, are suggested to potentially enhance the efficacy of photodynamic therapy by blocking ABCG2-mediated porphyrin efflux from cancer cells. This review article provides an overview on the role of human ABC transporter ABCG2 in photodynamic therapy and photodynamic diagnosis.