Extra-intestinal manifestations of Crohn's disease
Extra-intestinal manifestations of Crohn's disease
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DOI：
10.1016/j.suc.2007.03.003
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发表时间：
2007-06-01
影响因子：
3.1
通讯作者：
Ephgrave, Kimberly
中科院分区：
文献类型：
--
作者：
Ephgrave, Kimberly
至少25%的克罗恩病患者会出现肠外表现。一些肠外表现，如结节红斑和周围关节病，会随着肠道炎症的消长而消长。更严重的皮肤溃疡、葡萄膜炎和轴性关节病可能先于肠道疾病，或在肠道疾病消退后持续存在。筛查可能适用于眼病和骨质疏松症，以预防并发症。对肠外症状的医疗处理类似于对克罗恩病肠道症状的治疗，皮质类固醇是主要的治疗手段。疼痛和抑郁与炎症性肠病有关，它们的控制使患者受益。最近关于抗肿瘤坏死因子(TNF)药物的小规模研究有望治疗大多数克罗恩病的肠外表现，并可能在未来允许更多的类固醇非激素疾病控制。
Extra-intestinal manifestations occur in at least 25% of Crohn's disease patients. Some extra-intestinal manifestations, such as erythema nodusum and peripheral arthropathy, will wax and wane in keeping with bowel inflammation. The more severe cutaneous ulcerations, uveitis, and axial arthropathy may precede bowel disease or persist after it subsides. Screening may be appropriate for eye disease and for osteoporosis to prevent complications. Medical management for extra-intestinal manifestations is similar to treatment for the bowel symptoms of Crohn's disease, with corticosteroids the mainstay. Pain and depression are associated with inflammatory bowel disease, and their control benefits patients. Recent small studies with anti-tumor necrosis factor (TNF) agents are promising for most extra-intestinal manifestations of Crohn's disease, and may permit more steroid-sparing disease control in the future.