Visual discrimination among patients with depression and schizophrenia and healthy individuals using semiquantitative color-coded fast spin-echo T1-weighted magnetic resonance imaging
Visual discrimination among patients with depression and schizophrenia and healthy individuals using semiquantitative color-coded fast spin-echo T1-weighted magnetic resonance imaging
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DOI：
10.1007/s00234-009-0595-7
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发表时间：
2010-02-01
期刊：
影响因子：
2.8
通讯作者：
Sakai, Akio
中科院分区：
文献类型：
--
作者：
Sasaki, Makoto;Shibata, Eri;Sakai, Akio
快速自旋回波（FSE）T1加权（T1 W）磁共振成像（MRI）在3 T，这是敏感的神经黑色素相关的对比，可以定量检测信号改变，在蓝斑（LC）和黑质的丘脑（SNc）的抑郁症和精神分裂症患者，但是，其定性诊断性能仍然未知。我们调查了半定量彩色图的视觉解释是否可以用于区分抑郁症和精神分裂症患者和健康individuals.We回顾性研究了23例抑郁症患者，23例精神分裂症患者，和23名年龄匹配的健康对照组使用FSE-T1 W MRI技术。通过LC和SNc切片的半定量彩色图由9名评估者使用连续置信度评分量表进行受试者工作特征（ROC）分析，ROC曲线下面积（Az）为0.88，反映了区分抑郁症患者和对照组的性能，最大似然法的敏感性和特异性分别为76%和83%。相比之下，精神分裂症患者和对照组之间以及抑郁症患者和精神分裂症患者之间的Az值、灵敏度和特异性值分别为0.66和0.69、42%和48%、82%和84%.3T下的半定量、颜色编码的FSE-T1 W MRI可用于视觉上区分抑郁症患者和健康个体，具有相当高的可能性，但这种技术不能用于区分精神分裂症患者和其他两组患者。
Fast spin-echo (FSE) T1-weighted (T1W) magnetic resonance imaging (MRI) at 3T, which is sensitive to neuromelanin-related contrast, can quantitatively detect signal alterations in the locus ceruleus (LC) and the substantia nigra pars compacta (SNc) of depressive and schizophrenic patients; however, its qualitative diagnostic performance remains unknown. We investigated whether visual interpretation of semiquantitative color maps can be used for discriminating between depressive and schizophrenic patients and healthy individuals.We retrospectively examined 23 patients with major depression, 23 patients with schizophrenia, and 23 age-matched healthy controls by using a FSE-T1W MRI technique. Semiquantitative color maps of sections through the LC and SNc were visually interpreted by nine raters using a continuous confidence rating scale for receiver operating characteristic (ROC) analysis.The area under the ROC curve (Az), which reflects the performance in differentiating between depressive patients and controls, was 0.88, and the sensitivity and specificity at the maximum likelihood were 76% and 83%, respectively. In contrast, the Az value, sensitivity, and specificity values between schizophrenics and controls and between depressives and schizophrenics were 0.66 and 0.69, 42% and 48%, and 82% and 84%, respectively.Semiquantitative, color-coded FSE-T1W MRI at 3T can be used for visually differentiating depressive patients from healthy individuals with a substantially high likelihood, but this technique cannot be applied to distinguish schizophrenic patients from the other two groups.