Catching-up but telomere loss: half-opening the black box of growth and ageing trade-off in wild king penguin chicks
Catching-up but telomere loss: half-opening the black box of growth and ageing trade-off in wild king penguin chicks
复制标题
DOI：
10.1111/j.1365-294x.2011.05331.x
复制
发表时间：
2012-03-01
影响因子：
4.9
通讯作者：
Criscuolo, Francois
中科院分区：
文献类型：
--
作者：
Geiger, Sylvie;Le Vaillant, Maryline;Criscuolo, Francois
动物不能像它们可能的那样快速生长的原因之一是，快速生长已被证明与寿命缩短有关。然而，我们仍然缺乏对野生动物衰老机制的生长依赖性调节的现实的明确描述。使用特定的生长轨迹的小国王企鹅小鸡自然表现出高于正常的增长率，以弥补冬季休息，我们测试是否氧化应激和端粒缩短与生长轨迹。血浆抗氧化防御，氧化损伤水平和端粒长度进行了测量，在开始时和结束后的冬季生长期在三组小鸡（小鸡，无论是死亡或存活的生长期，和大鸡）。在生长期早期死亡的小鸡在死亡前具有最高水平的氧化损伤和最短的端粒长度。在这里，我们表明，小鸡生长得更快，这不利于身体的维护机制，如（i）更高的氧化损伤和（ii）加速端粒丢失。我们的研究为自然条件下生长和衰老率之间的机械联系提供了第一个证据。
One of the reasons for animals not to grow as fast as they potentially could is that fast growth has been shown to be associated with reduced lifespan. However, we are still lacking a clear description of the reality of growth-dependent modulation of ageing mechanisms in wild animals. Using the particular growth trajectory of small king penguin chicks naturally exhibiting higher-than-normal growth rate to compensate for the winter break, we tested whether oxidative stress and telomere shortening are related to growth trajectories. Plasma antioxidant defences, oxidative damage levels and telomere length were measured at the beginning and at the end of the post-winter growth period in three groups of chicks (small chicks, which either passed away or survived the growth period, and large chicks). Small chicks that died early during the growth period had the highest level of oxidative damage and the shortest telomere lengths prior to death. Here, we show that small chicks that grew faster did it at the detriment of body maintenance mechanisms as shown by (i) higher oxidative damage and (ii) accelerated telomere loss. Our study provides the first evidence for a mechanistic link between growth and ageing rates under natural conditions.