Note: Integration of trapped ion mobility spectrometry with mass spectrometry
Note: Integration of trapped ion mobility spectrometry with mass spectrometry
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DOI：
10.1063/1.3665933
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发表时间：
2011-12-01
影响因子：
1.6
通讯作者：
Park, M. A.
中科院分区：
文献类型：
--
作者：
Fernandez-Lima, F. A.;Kaplan, D. A.;Park, M. A.
描述了捕获离子迁移谱仪（TIMS）与质谱仪（MS）的集成，用于互补快速，质分析前气相迁移分离（TIMS-MS）。讨论了离子源条件、浴气速度、分析扫描速度、射频离子约束和下游离子光学条件对离子传输和迁移率分离的影响。TIMS迁移分辨率取决于分析扫描速度和浴气速度，其独特的优势是IMS分离可以很容易地从高速（类似于25 ms）进行快速分析调整到较慢的扫描以获得更高的迁移分辨率（R > 80）。(C) 2011年美国物理研究所。(doi: 10.1063/1.3665933)
The integration of a trapped ion mobility spectrometer (TIMS) with a mass spectrometer (MS) for complementary fast, gas-phase mobility separation prior to mass analysis (TIMS-MS) is described. The ion transmission and mobility separation are discussed as a function of the ion source condition, bath gas velocity, analysis scan speed, RF ion confinement, and downstream ion optical conditions. TIMS mobility resolution depends on the analysis scan speed and the bath gas velocity, with the unique advantage that the IMS separation can be easily tuned from high speed (similar to 25 ms) for rapid analysis to slower scans for higher mobility resolution (R > 80). (C) 2011 American Institute of Physics. [doi:10.1063/1.3665933]