Clerodane diterpenoids from the Chinese liverwort Jamesoniella autumnalis and their anti-inflammatory activity
Clerodane diterpenoids from the Chinese liverwort Jamesoniella autumnalis and their anti-inflammatory activity
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地钱中的 Clerodane 二萜及其抗炎活性
DOI：
10.1016/j.phytochem.2018.06.013
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发表时间：
2018-10-01
期刊：
影响因子：
3.8
通讯作者：
Lou, Hongxiang
中科院分区：
文献类型：
--
作者：
Li, Yi;Zhu, Rongxiu;Lou, Hongxiang
从中国地钱Jamesoniellaautumnalis（DC.）史蒂芬妮它们的结构用MS，NMR光谱和电子圆二色谱（ECD）计算确定。本文研究了Jamesoniellides Q-S对LPS诱导的小鼠巨噬细胞NO生成的抑制作用，结果表明，Jamesoniellides Q-S具有中等程度的抗炎活性，在无毒试验浓度下对NO生成的最大抑制率为50-80%。
Nine previously undescribed clerodane-type diterpenoids, jamesoniellides M - T and one ent-labdane-type diterpenoid, as well as one known analogue, were isolated from the Chinese liverwort Jamesoniella autumnalis (DC.) Stephani. Their structures were determined using MS, NMR spectroscopy, and electronic circular dichroism (ECD) calculations. Inhibition on LPS-induced NO production in RAW 264.7 murine macrophages was investigated, and the results showed that jamesoniellides Q - S exhibited moderate anti-inflammatory activity, with 50-80% maximum inhibition rate of NO production under the nontoxic tested concentration.