Phylogenomic evolutionary surveys of subtilase superfamily genes in fungi.
Phylogenomic evolutionary surveys of subtilase superfamily genes in fungi.
复制标题
真菌枯草杆菌酶超家族基因的系统发育进化调查。
DOI：
10.1038/srep45456
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发表时间：
2017-03-30
影响因子：
4.6
通讯作者：
Zhang KQ
中科院分区：
文献类型：
--
作者：
Li J;Gu F;Wu R;Yang J;Zhang KQ
枯草杆菌酶属于丝氨酸蛋白酶的超家族，其在真菌中普遍存在，并且被怀疑具有不同的功能特性以帮助真菌适应不同的生态位。在这项研究中，我们进行了一个大规模的枯草杆菌酶蛋白酶基因的全基因组测序的83种真菌物种，以确定不同的枯草杆菌酶家族的真菌王国的主要谱系之间的进化模式和随后的功能分歧。我们对枯草杆菌酶超家族的比较基因组分析表明，真菌中发生了广泛的基因复制、丢失和功能多样性，真菌中的四个枯草杆菌酶家族，包括蛋白酶K样、Pyrolisin、kexin和S53，具有不同的进化历史，这可能促进了真菌适应广泛的生活策略。我们的研究为真菌中枯草杆菌酶超家族的进化提供了新的见解，并扩展了我们对不同生活方式真菌进化的理解。
Subtilases belong to a superfamily of serine proteases which are ubiquitous in fungi and are suspected to have developed distinct functional properties to help fungi adapt to different ecological niches. In this study, we conducted a large-scale phylogenomic survey of subtilase protease genes in 83 whole genome sequenced fungal species in order to identify the evolutionary patterns and subsequent functional divergences of different subtilase families among the main lineages of the fungal kingdom. Our comparative genomic analyses of the subtilase superfamily indicated that extensive gene duplications, losses and functional diversifications have occurred in fungi, and that the four families of subtilase enzymes in fungi, including proteinase K-like, Pyrolisin, kexin and S53, have distinct evolutionary histories which may have facilitated the adaptation of fungi to a broad array of life strategies. Our study provides new insights into the evolution of the subtilase superfamily in fungi and expands our understanding of the evolution of fungi with different lifestyles.