In vitro hemodynamic investigation of the embryonic aortic arch at late gestation
In vitro hemodynamic investigation of the embryonic aortic arch at late gestation
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DOI：
10.1016/j.jbiomech.2008.03.013
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发表时间：
2008-01-01
影响因子：
2.4
通讯作者：
Yoganathan, Ajit
中科院分区：
文献类型：
--
作者：
Pekkan, Kerem;Dasi, Lakshmi P.;Yoganathan, Ajit
这项研究的重点是左右心室同时动作驱动的通过胎儿主动脉弓的动态血流。我们创建了具有生理血管几何形状的胎儿主动脉连接处的参数脉动计算流体动力学 (CFD) 模型。为了获得更好的生物物理学理解，针对相同的 CFD 条件构建了用于流动可视化的体外实验胎儿流动回路。 CFD 和体外实验结果具有可比性。在肺动脉（PA）、头颈血管和降主动脉中观察到心动周期加速期的旋流和中期减速期后的单向流。从右向左（含氧）血液流过相对于顺行左心室流出道（LVOT）流后方的动脉导管（DA），类似于射流。直到 DA 插入主动脉弓下游约 3.5 倍降主动脉直径时，LVOT 和右心室流出道血流混合才完成。然后将正常弓模型血流模式与包括主动脉弓异常在内的四种常见先天性心脏畸形的血流模式进行比较。仅在法洛四联症构型中观察到通过 DA 连接点的微弱振荡反向流动。 PA 和左心发育不全综合征的配置表现出 PA 和头颈血管中复杂、异常的血流模式。主动脉缩窄导致 DA 附近的主动脉弓出现大规模再循环血流。血管内血流模式与异常血管结构在空间上相关，这与先天性心脏病相关的异常血管内血流模式影响血管生长和功能的范式一致。 (C) 2008 Elsevier Ltd. 保留所有权利。
This study focuses on the dynamic flow through the fetal aortic arch driven by the concurrent action of right and left ventricles. We created a parametric pulsatile computational fluid dynamics (CFD) model of the fetal aortic junction with physiologic vessel geometries. To gain a better biophysical understanding, an in vitro experimental fetal flow loop for flow visualization was constructed for identical CFD conditions. CFD and in vitro experimental results were comparable. Swirling flow during the acceleration phase of the cardiac cycle and unidirectional flow following mid-deceleration phase were observed in pulmonary arteries (PA), head-neck vessels, and descending aorta. Right-to-left (oxygenated) blood flowed through the ductus arteriosus (DA) posterior relative to the antegrade left ventricular outflow tract (LVOT) stream and resembled jet flow. LVOT and right ventricular outflow tract flow mixing had not completed until similar to 3.5 descending aorta diameters downstream of the DA insertion into the aortic arch. Normal arch model flow patterns were then compared to flow patterns of four common congenital heart malformations that include aortic arch anomalies. Weak oscillatory reversing flow through the DA junction was observed only for the Tetralogy of Fallot configuration. PA and hypoplastic left heart syndrome configurations demonstrated complex, abnormal flow patterns in the PAs and head-neck vessels. Aortic coarctation resulted in large-scale recirculating flow in the aortic arch proximal to the DA. Intravascular flow patterns spatially correlated with abnormal vascular structures consistent with the paradigm that abnormal intravascular flow patterns associated with congenital heart disease influence vascular growth and function. (C) 2008 Elsevier Ltd. All rights reserved.