Palladium-Catalyzed Enantioselective C-H Aminocarbonylation: Synthesis of Chiral Isoquinolinones
Palladium-Catalyzed Enantioselective C-H Aminocarbonylation: Synthesis of Chiral Isoquinolinones
复制标题
钯催化的对映选择性 C-H 氨基羰基化：手性异喹啉酮的合成
DOI：
10.1021/acs.orglett.9b00315
复制
发表时间：
2019-03-15
期刊：
影响因子：
5.2
通讯作者：
Xia, Ji-Bao
中科院分区：
文献类型：
--
作者：
Han, Hui;Zhang, Tao;Xia, Ji-Bao
以市售的L焦谷氨酸为手性配体，制备了钯催化的不对称对映体选择性C-H羰基化反应。异喹诺酮类化合物的合成具有产率高、对映体选择性高等优点。机理研究和密度泛函理论计算提供了合理的反应途径。
A Pd-catalyzed enantioselective C-H carbonylation by desymmetrization was developed with commercially available L-pyroglutamic acid as chiral ligand. Isoquinolinones were successfully obtained with good yields and high enantioselectivities. Mechanistic studies and DFT calculations provided a reasonable reaction pathway.