Clostridium difficile infection in patients discharged from US short-stay hospitals, 1996-2003
Clostridium difficile infection in patients discharged from US short-stay hospitals, 1996-2003
复制标题
DOI：
10.3201/eid1203.051064
复制
发表时间：
2006-03-01
影响因子：
11.8
通讯作者：
Jernigan, DB
中科院分区：
文献类型：
--
作者：
McDonald, LC;Owings, M;Jernigan, DB
被诊断为艰难梭菌相关性疾病(CDAD)的美国医院出院人数从1996年的82,000(95%可信区间[CI]71,000-94,000)或31/100,000人增加了一倍至2003年的178,000(95%CI为151,000-205,000)或61/100,000；这一增长在2000至2003年间显著增加(斜率为线性趋势9.48；95%CI为6.16-12.80，p=0.01)。在此期间，65岁人群的总体发病率(228/100,000)比发病率第二高的45-年龄组(40/100,000；P<；0.001)高出数倍。CDAD在美国似乎正在迅速增加，而且对老年人的影响不成比例。临床医生应该意识到CDAD的风险增加，并努力控制艰难梭菌的传播，预防疾病。
US hospital discharges for which Clostridium difficile-associated disease (CDAD) was listed as any diagnosis doubled from 82,000 (95% confidence interval [CI] 71,000-94,000) or 31/100,000 population in 1996 to 178,000 (95% Cl 151,000-205,000) or 61/100,000 in 2003; this increase was significant between 2000 and 2003 (slope of linear trend 9.48; 95% Cl 6.16-12.80, p = 0.01). The overall rate during this period was severalfold higher in persons > 65 years of age (228/100,000) than in the age group with the next highest rate, 45-64 years (40/100,000; p < 0.001). CDAD appears to be increasing rapidly in the United States and is disproportionately affecting older persons. Clinicians should be aware of the increasing risk for CDAD and make efforts to control transmission of C. difficile and prevent disease.