OXIDANTS, ANTIOXIDANTS, AND RESPIRATORY-TRACT LINING FLUIDS
OXIDANTS, ANTIOXIDANTS, AND RESPIRATORY-TRACT LINING FLUIDS
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DOI：
10.2307/3432237
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发表时间：
1994-12-01
影响因子：
10.4
通讯作者：
HALLIWELL, B
中科院分区：
文献类型：
--
作者：
CROSS, CE;VANDERVLIET, A;HALLIWELL, B
呼吸道内膜液 (RTLF) 是一组异质物质，覆盖从鼻粘膜到肺泡的呼吸道上皮细胞 (RTEC)。 RTLF 中含有的抗氧化剂有望对吸入的环境毒素提供初步防御。 RTLF 中的主要抗氧化剂包括粘蛋白、尿酸、蛋白质（主要是白蛋白）、抗坏血酸和还原型谷胱甘肽 (GSH)。 RTLF抗氧化剂可以通过血浆成分的渗出/渗出等过程来增强； RTEC 分泌过程，包括腺体粘液分泌；以及源自 RTEC 和炎症细胞裂解的细胞抗氧化剂。 RTLF 的抗氧化成分及其在氧化应激条件下调节正常和病理生理 RTEC 功能中的作用尚未得到充分表征。
Respiratory tract lining fluids (RTLFs) are a heterogeneous group of substances covering the respiratory tract epithelial cells (RTECs) from nasal mucosa to alveoli. Antioxidants contained in the RTLFs can be expected to provide an initial defense against inhaled environmental toxins. The major antioxidants in RTLF include mucin, uric acid, protein (largely albumin), ascorbic acid, and reduced glutathione (GSH). RTLF antioxidants can be augmented by such processes as transudation/exudation of plasma constituents; RTEC secretory processes, including glandular mucus secretion; and cellular antioxidants derived from lysis of RTECs and of inflammatory cells. The antioxidant composition of RTLFs and their role in modulating normal and pathophysiologic RTEC functions under conditions of oxidative stress are yet to be fully characterized.