Hyperbranched poly(N-(2-hydroxypropyl)methacrylamide) via RAFT self-condensing vinyl polymerization
Hyperbranched poly(N-(2-hydroxypropyl)methacrylamide) via RAFT self-condensing vinyl polymerization
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DOI：
10.1039/c6py00111d
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发表时间：
2016-01-01
影响因子：
4.6
通讯作者：
Sumerlin, Brent S.
中科院分区：
文献类型：
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作者：
Alfurhood, Jawaher A.;Sun, Hao;Sumerlin, Brent S.
报道了用可逆加成-断裂链转移(RAFT)自缩合乙烯基聚合法(SCVP)合成超支化聚(N-(2-羟丙基)甲基丙烯酰胺)(HB-PHPMA)。这些复杂、明确的结构的合成涉及到HPMA与链转移单体(CTM)的共聚。研究了聚合反应动力学，考察了引发剂浓度、单体与CTM摩尔比对聚合反应的影响。合成的聚合物具有高相对分子质量和可控制的支化频率。由于其固有的两亲性，这些超支化结构在水中自组装成聚集体。此外，我们确定HB-PHPMA的浊点在亚环境温度到40摄氏度的范围内。这种方法提供了一种新型的热响应性PHPMA聚合物，具有潜在的药物输送和其他生物应用。
We report the first synthesis of hyperbranched poly(N-(2-hydroxypropyl)methacrylamide) (HB-PHPMA) using reversible addition-fragmentation chain transfer (RAFT) self-condensing vinyl polymerization (SCVP). The synthesis of these complex, well-defined architectures involved the copolymerization of HPMA with a chain transfer monomer (CTM). The polymerization kinetics, as well as the effects of initiator concentration and the ratio of monomer to CTM were studied. The resulting polymers show high molecular weights and controlled branching frequencies. Due to their inherent amphiphilic nature, these hyperbranched structures self-assemble into aggregates in water. Additionally, we determined the cloud point of the HB-PHPMA to be in the range of sub-ambient temperature to 40 degrees C. This approach provides access to a new class of thermoresponsive PHPMA polymers with potential to be used in drug delivery and other biological applications.