After AIDS clinical trial 076: the changing pattern of zidovudine use during pregnancy, and the subsequent reduction in the vertical transmission of human immunodeficiency virus in a cohort of infected women and their infants. Women and Infants Transmissi
After AIDS clinical trial 076: the changing pattern of zidovudine use during pregnancy, and the subsequent reduction in the vertical transmission of human immunodeficiency virus in a cohort of infected women and their infants. Women and Infants Transmissi
复制标题
艾滋病临床试验 076 后：怀孕期间齐多夫定使用模式的变化，以及随后在一组受感染妇女及其婴儿中人类免疫缺陷病毒垂直传播的减少。
DOI：
10.1093/infdis/174.6.1207
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Fowler,MG
中科院分区：
文献类型：
--
作者：
Cooper,ER;Nugent,RP;Diaz,C;Pitt,J;Hanson,C;Kalish,LA;Mendez,H;Zorrilla,C;Hershow,R;Moye,J;Smeriglio,V;Fowler,MG
To determine the impact of the AIDS Clinical Trials Group (ACTG) Protocol 076 results on the subsequent use of zidovudine during pregnancy and the transmission rate of human immunodeficiency virus (HIV) in a cohort of mother-infant pairs (Women and Infants Transmission Study), a retrospective analysis was done. Transmission rates were calculated by simple proportion for infants with at least 6 months of follow-up, stratified by date of birth (n= 453 born on or before 1 March 1994;n= 103 born after 1 March 1994). Transmission rates decreased from 19% to 8% (P= .005, Fisher's exact test). Zidovudine use increased during pregnancy (22% vs. 89%) and in newborns (1% vs. 79%). Both cohorts were similar with respect to maternal immunosuppression, mode of delivery, and demographics. In summary, in a perinatal HIV observational study, the release of results of ACTG Protocol 076 was associated with an increase in zidovudine use during pregnancy and a concomitant decline in HIV transmission from mothers to infants.
