PRONOUNCED LOWERING OF SERUM LEVELS OF LIPOPROTEIN LP(A) IN HYPERLIPEMIC SUBJECTS TREATED WITH NICOTINIC-ACID
PRONOUNCED LOWERING OF SERUM LEVELS OF LIPOPROTEIN LP(A) IN HYPERLIPEMIC SUBJECTS TREATED WITH NICOTINIC-ACID
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DOI：
10.1111/j.1365-2796.1989.tb01393.x
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发表时间：
1989-10-01
影响因子：
11.1
通讯作者：
ASPLUND, A
中科院分区：
文献类型：
--
作者：
CARLSON, LA;HAMSTEN, A;ASPLUND, A
连续31例高血压病患者每天用4 g烟酸治疗6周。治疗前后测定血清脂蛋白Lp（a）浓度及主要脂蛋白种类。烟酸能显著降低整个患者组的血清Lp（a）水平。线性回归分析显示Lp（a）下降百分比与治疗前血清甘油三酯水平呈强负相关（r = -0.78），提示血清甘油三酯浓度高于7.5mmol l-1的患者Lp（a）升高。在排除血清甘油三酯水平高于10 mmol l-1的4例患者后，计算Lp（a）浓度的平均个体百分比降低。下降38%，95%置信区间为28- 47%。Lp（a）的绝对下降与治疗前水平相关（r = 0.91）。全组Lp（a）下降百分率与LDL胆固醇下降百分率呈直线相关（r = 0.88）。后一种强相关性可能是由于抑制了两种脂蛋白共有的蛋白质--载脂蛋白B的合成。
Thirty-one consecutive unselected hyperlipidemic patients were treated daily with 4 g of nicotinic acid for 6 weeks. The concentrations in serum of lipoprotein Lp(a), and the major lipoprotein classes, were determined before and after the treatment. Nicotinic acid significantly reduced the serum levels of Lp(a) in the whole patient group. Linear regression analysis showed a strong negative relationship between the percentage reduction of Lp(a) and the serum triglyceride level before treatment (r = -0.78), which implied that for patients with a serum triglyceride concentration above 7.5 mmol l-1 there was a rise of Lp(a). The average individual percentage decrease of the concentration of Lp(a) was calculated after the exclusion of four patients who had serum triglyceride levels above 10 mmol l-1. The decrease was 38% with a 95% confidence interval of 28-47%. The absolute decrease of Lp(a) was correlated with the pretreatment levels of Lp(a) (r = 0.91). Within the whole group of patients there was a linear relationship between the percentage decrease of Lp(a) and that of LDL cholesterol (r = 0.88). This latter strong relationship might be due to an inhibition of the synthesis of the protein common to the two lipoproteins, apolipoprotein B.