Pregnancy outcomes in in vitro fertilization in 17-alpha-hydroxylase deficiency.
Pregnancy outcomes in in vitro fertilization in 17-alpha-hydroxylase deficiency.
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DOI：
10.1016/j.xfre.2023.02.012
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发表时间：
2023-06
期刊：
影响因子：
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通讯作者：
DeCherney A
中科院分区：
文献类型：
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作者：
van Oosbree A;Asif A;Hmaidan S;DeCherney A
自1966年描述了第一例17-α-羟化酶缺乏症（17-OHD）以来，已报告了许多具有高血压、低钾血症和性腺功能减退症临床表现的病例。不孕不育是其中一些人的主要担忧。这篇小型综述旨在详细介绍这种疾病影响生育力的组成部分，并重点关注最近成功实现活产的加速，以及突出不成功的尝试。支持成功活产的数据仍然有限，但现有证据表明，体外受精可与激素替代疗法和类固醇抑制联合使用，以实现17-OHD不孕症患者的活产。
Since the first case of 17-alpha-hydroxylase-deficiency (17-OHD) was described in 1966, a number of cases have been reported with a clinical picture of hypertension, hypokalemia, and hypogonadism. Infertility is a major concern for some of these individuals. This mini-review aims to detail the components of this disorder that affect fertility and focus on the recent acceleration in the success of achieving live births, as well as highlight the unsuccessful attempts. The data supporting successful live births remains limited, but existing evidence suggests that in vitro fertilization can be used in conjunction with hormone replacement therapy and steroid suppression to achieve live birth in patients with infertility from 17-OHD.