CONTRACTILE MECHANICS AND INTERACTION OF THE RIGHT AND LEFT-VENTRICLES
CONTRACTILE MECHANICS AND INTERACTION OF THE RIGHT AND LEFT-VENTRICLES
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DOI：
10.1016/0002-9149(81)90556-7
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发表时间：
1981-01-01
影响因子：
2.8
通讯作者：
FISHMAN, AP
中科院分区：
文献类型：
--
作者：
WEBER, KT;JANICKI, JS;FISHMAN, AP
心脏和肺，以及血红蛋白，提供氧气从大气到代谢组织的运输。血液的氧合和含氧血液的循环精确地同步，使得心脏和肺构成完整的心肺单元。心肺功能的整合是通过它们的解剖结构和机械相互作用来促进的。心肺单元由右心室和左心室（两个由心肌组成的串联泵）组成，它们通过肺机械耦合。控制心肌缩短的因素（纤维长度、后负荷和心肌收缩状态）也调节每个心室的泵送行为。因为心室是串联排列的，所以一个心室的机械事件的扰动将影响另一个心室的行为。室间隔和心包进一步促进心室之间的机械相互作用。胸内压（心肺单元周围的压力）在心室以及心脏和肺之间产生额外的相互作用。
The heart and lungs, together with hemoglobin, provide for the transport of oxygen from the atmosphere to the metabolizing tissue. The oxygenation of blood and the circulation of oxygenated blood are precisely synchronized so that the heart and lungs constitute an integrated cardiopulmonary unit. The functional integration of the heart and lungs is fostered by their anatomic arrangement and mechanical interaction.The cardiopulmonary unit consists of the right and left ventricles (two in-series pumps composed of cardiac muscle), which are mechanically coupled by the lungs. The factors that control cardiac muscle shortening (fiber length, afterload and myocardial contractile state) also regulate the pumping behavior of each ventricle. Because the ventricles are aligned in series a perturbation in the mechanical events of one ventricle will influence the behavior of the other ventricle. The interventricular septum and pericardium further promote the mechanical interplay between ventricles. Intrathoracic pressure (the pressure that surrounds the cardiopulmonary unit) creates an additional interaction between the ventricles as well as the heart and lungs.