Modified technique for production of experimental right-sided congestive heart failure.
Modified technique for production of experimental right-sided congestive heart failure.
复制标题
用于生产实验性右侧充血性心力衰竭的改良技术。
DOI：
10.1093/cvr/7.6.870
复制
发表时间：
1973
影响因子：
10.8
通讯作者：
S. Vatner
中科院分区：
文献类型：
--
作者：
C. Higgins;R. Pavelec;S. Vatner
实验性心力衰竭是由三尖瓣前小叶的手指撕脱导致的三尖瓣功能不全和肺动脉底部植入的动脉周围水力闭塞器的进行性扩张导致的进行性肺狭窄引起的。这项技术的优势在于，它允许外部调节肺闭塞程度，并且与可忽略不计的手术死亡率相关，并且始终产生心力衰竭的狗，但在许多月内仍保持健康。
Experimental heart failure was produced by tricuspid insufficiency accomplished by digital avulsion of the anterior leaflet of the tricuspid valve and progressive pulmonary stenosis by progressive distension of a periarterial hydraulic occluder implanted at the base of the pulmonary artery. This technique is advantageous because it allows external regulation of the degree of pulmonary occlusion and is associated with a negligible operative mortality and consistently produces dogs with heart failure which remain otherwise healthy for many months.