Common genetic variants in ADCY5 and gestational glycemic traits
Common genetic variants in ADCY5 and gestational glycemic traits
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ADCY5 和妊娠血糖特征的常见遗传变异
DOI：
10.1371/journal.pone.0230032
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发表时间：
2020-03-12
期刊：
影响因子：
3.7
通讯作者：
Jin, Li
中科院分区：
文献类型：
--
作者：
Lin, Rong;Yuan, Ziyu;Jin, Li
两项全基因组相关性研究的荟萃分析发现，在欧洲血统的非怀孕个体中，腺苷环化酶5(ADCY5)的两个变异与2型糖尿病、空腹和2小时血糖有关。本研究的目的是探讨中国汉族妇女妊娠期血糖、胰岛素水平、β细胞功能、空腹胰岛素抵抗以及50g葡萄糖负荷试验后1小时血糖的变化。β细胞功能(HOMA1-β和HOMA2-β)和胰岛素抵抗(HOMA1-IR和HOMA2-IR)采用稳态模型评估(HOMA)。对929例无血缘关系的汉族单胎妊娠妇女进行了ADCY5基因的35个单核苷酸多态(SNPs)基因分型。3个SNP(rs6797915、rs9856662和rs9875803)在50g葡萄糖负荷试验后1小时显示与血糖相关(P分别为0.042、0.018和0.018)，1个(Rs6777397)与HOMA1-β相关(P=0.014)，1个(Rs6762009)与HOMA1-IR相关(P=0.033)。这些结果进一步揭示了ADCY5基因变异对葡萄糖代谢的影响，特别是在妊娠期和非欧洲血统人群中。
Two meta-analysis of genome wide association studies identified two variants at adenylate cyclase 5 (ADCY5) associated with type 2 diabetes mellitus, fasting and 2-hour glucose in non-pregnant individuals of European descent. The objective of our study was to explore the role of common variants in ADCY5 on gestational glycemic traits, including plasma glucose, insulin values, β cell function and insulin resistance in the fasted state as well as plasma glucose 1 hour after a 50-gram glucose challenge test among Chinese Han women. Homoeostasis model assessment (HOMA) was used to quantify β cell function (HOMA1-β and HOMA2-β) and insulin resistance (HOMA1-IR and HOMA2-IR). Thirty-five single nucleotide polymorphisms (SNPs) in ADCY5 were genotyped in 929 unrelated Chinese Han women with singleton pregnancies. Three SNPs (rs6797915, rs9856662 and rs9875803) displayed evidence for association with plasma glucose 1 hour after a 50-gram glucose challenge test (P = 0.042, 0.018 and 0.018, respectively), one (rs6777397) displayed evidence for association with HOMA1-β (P = 0.014), and one (rs6762009) displayed evidence for association with HOMA1-IR (P = 0.033). These results provide additional insight into the effects of genetic variation within ADCY5 in glucose metabolism, especially during pregnancy and in non-European descent populations.