Smoking at onset of rheumatoid arthritis (RA) and its effect on disease activity and functional status: experiences from BARFOT, a long-term observational study on early RA
Smoking at onset of rheumatoid arthritis (RA) and its effect on disease activity and functional status: experiences from BARFOT, a long-term observational study on early RA
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DOI：
10.3109/03009742.2010.541495
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发表时间：
2011-01-01
影响因子：
2.1
通讯作者：
Svensson, B.
中科院分区：
文献类型：
--
作者：
Soderlin, M. K.;Petersson, I. F.;Svensson, B.
目的：为了评估吸烟对早期类风湿关节炎（RA）患者的疾病结局的影响，方法：1996年至2004年，1787例成人患者（病程5.1，p = 0.005）。与从不吸烟者（36%）和既往吸烟者（42%）相比，12个月时缓解的当前吸烟者（33%）显著较少（p = 0.013）。目前的吸烟在列入独立预测不良EULAR响应长达12个月的follow-up.Conclusion：本研究提供了一些支持早期的数据表明，RA患者吸烟有一个更活跃的疾病，但需要进一步的研究来证实这一点。
Objectives: To assess the effects of smoking on disease outcome in a large cohort of patients with early rheumatoid arthritis (RA).Methods: Between 1996 and 2004, 1787 adult patients (disease duration 5.1, p = 0.005). Significantly fewer current smokers were in remission at 12 months (33%) compared to never smokers (36%) and previous smokers (42%) (p = 0.013). Current smoking at inclusion independently predicted poor EULAR response up to 12 months of follow-up.Conclusion: The present study gives some support to earlier data indicating that RA patients who smoke have a more active disease but further studies are needed to confirm this.