The Effect of Verapamil on Experimental Myocardial Ischaemia with a Particular Reference to Regional Myocardial Blood Flow and Metabolism *
The Effect of Verapamil on Experimental Myocardial Ischaemia with a Particular Reference to Regional Myocardial Blood Flow and Metabolism *
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维拉帕米对实验性心肌缺血的影响，特别是对局部心肌血流和代谢的影响 *
DOI：
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发表时间：
1977
期刊：
影响因子：
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通讯作者：
P. J. Hurley
中科院分区：
文献类型：
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作者：
H. J. Smith;B. Singh;R. Norris;Heather D. Nisbet;M. B. John;P. J. Hurley
摘要：本文研究了维拉帕米对左冠状动脉前降支闭塞术后开胸麻醉犬心外膜ST段抬高、局部心肌代谢和侧支血流量的影响。采用放射性微球（直径15±5 μ）测定侧枝血流量，测定梗死心肌静脉血乳酸浓度研究局部代谢。维拉帕米（静脉注射0 - 2mg /kg）在冠状动脉闭塞前给药可显著降低心外膜ST段抬高（50-60%）；在冠状动脉闭塞后15分钟给药，并持续输注2小时，可将ST段抬高降至最低（30-40%），并防止未治疗的ST段持续升高的动物心脏指数下降和全身阻力上升。心外膜ST段发生改变，但QRS持续时间不变。维拉帕米对缺血性心室心肌的总侧支血流量及心内膜和心外膜的相对血流分布均无影响。当对照动物与维拉帕米治疗的动物相比，从梗塞中心的心外膜小静脉中采集的血液中乳酸水平没有明显差异。
Summary: The effects of verapamil on epicardial ST segment elevation, regional myocardial metabolism and collateral blood flow were studied in open‐chest anesthetized dogs following left anterior descending coronary artery occlusion. Collateral blood flow was measured by radioactive microspheres (15 ± 5 μ diameter) and regional metabolism was studied by measuring lactate concentration in venous blood draining the infarcting myocardium. Verapamil (0–2 mg/kg intravenously) produced a significant reduction (50–60%) in the epicardial ST elevation when it was given before coronary occlusion; when administered 15 minutes after coronary occlusion and infusion continued for two hours, it minimized (30–40%) ST segment elevation, and prevented the fall in cardiac index and rise in systemic resistance found in the untreated animals in which the ST segment remained persistently elevated. Changes in epicardial ST segment occurred without alterations in the QRS duration. Verapamil had no effect on either the total collateral blood flow or the relative distribution of flow to the endocardial and epicardial halves of the ischemic ventricular myocardium. No significant differences were found between the levels of lactate in blood sampled from small epicardial veins at the center of the infarct when the control animals were compared with those treated with verapamil.