Ethyl pyruvate: a novel treatment for sepsis and shock.
Ethyl pyruvate: a novel treatment for sepsis and shock.
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作者：
M. Fink
丙酮酸是一种简单的3碳酮基单羧酸。认识到丙酮酸是活性氧物种(ROS)的有效清除剂，促使研究人员将其用作各种病理情况的治疗剂，这些疾病被认为是由氧化还原依赖现象介导的，如心肌、肠道或肝脏缺血/再灌注损伤。丙酮酸乙酯比等摩尔剂量的丙酮酸钠更有效、更安全。丙酮酸乙酯具有抗炎作用。在动物模型中，丙酮酸乙酯改善了内毒素血症引起的高通透性和细菌易位，改善了肾功能障碍的发展，并改善了一些肾脏损伤的形态学表现。EP抗炎作用的药理基础尚不清楚。EP可能通过抑制核因子-kB的活化、NO和促炎细胞因子的分泌而起作用。
Pyruvic acid is a simple 3 carbon a-keto-monocarboxylic acid. Recognition that pyruvate is an effective scavenger of reactive oxygen species (ROS) prompted investigators to use it as therapeutic agent for various pathological conditions that are thought to be mediated by redox dependent phenomena, like myocardial, intestinal or hepatic ischemia/reperfusion-induced injury. Ethyl Pyruvate showed to be more effective and safer than equimolar doses of sodium pyruvate. Ethyl Pyruvate showed to have anti-inflammatory effects. In animal models Ethyl Pyruvate improved hyperpermeability and bacterial translocation due to endotoxemia and improved the development of renal disfunction as well as some of the morphological findings of kidney injury. The pharmacological basis for the anti-inflammatory effects of EP remains to be explained. It is plausible that EP mediates suppression of NF-KB activation and secretion of NO and of pro-inflammatory cytokines.