VALUE OF ECHOCARDIOGRAPHIC MEASUREMENT OF LEFT-VENTRICULAR MASS IN PREDICTING CARDIOVASCULAR MORBID EVENTS IN HYPERTENSIVE MEN
VALUE OF ECHOCARDIOGRAPHIC MEASUREMENT OF LEFT-VENTRICULAR MASS IN PREDICTING CARDIOVASCULAR MORBID EVENTS IN HYPERTENSIVE MEN
复制标题
DOI：
10.7326/0003-4819-105-2-173
复制
发表时间：
1986-08-01
影响因子：
39.2
通讯作者：
LARAGH, JH
中科院分区：
文献类型：
--
作者：
CASALE, PN;DEVEREUX, RB;LARAGH, JH
为了评估超声心动图和心电图检测左心室肥厚是否可以预测单纯性高血压患者的心血管疾病事件，我们对140名男性进行了平均4.8年的随访。111例患者的初始超声心动图测量左心室质量正常（< 125 g/m2体表面积），29例患者显示肥厚。超声心动图显示心肌肥厚患者中发生的疾病事件（7/29，4.6/100患者-年）多于心室质量正常患者（7/111，1.4/100患者-年; p < 0.01）。心电图显示心肌肥厚的患者太少，没有预测价值。多元Logistic回归分析显示，左心室质量指数对未来事件的独立相对风险最高，收缩压和舒张压以及年龄的相对风险略低。在轻度无并发症的高血压男性患者中，超声心动图检测到的左心室肥大可识别心血管疾病事件的高风险患者，并且是未来疾病事件的重要风险因素，与年龄、血压或静息心室功能无关。
To assess whether echocardiographic and electrocardiographic detection of left ventricular hypertrophy could predict cardiovascular morbid events in patients with uncomplicated essential hypertension, we followed 140 men for a mean of 4.8 years. Initial echocardiographic measurements of left ventricular mass were normal (< 125 g/m2 body surface area) in 111 patients and revealed hypertrophy in 29 patients. Morbid events occurred in more patients with hypertrophy on echocardiography (7 or 29, 4.6/100 patients-years) than with normal ventricular mass (7 of 111, 1.4/100 patient-years; p < 0.01). Electrocardiography showed hypertrophy in too few patients to be of predictive value. Multiple logistic regression analysis showed that left ventricular mass index had the highest independent relative risk for future events and that systolic and diastolic pressures and age had slightly lower relative risks. In men with mild uncomplicated hypertension, left ventricular hypertrophy detected by echocardiography identifies patients at high risk for cardiovascular morbid events and is a significant risk factor for future morbid events independent of age, blood pressure, or resting ventricular function.