Candidal overgrowth in diabetic patients: potential predisposing factors
Candidal overgrowth in diabetic patients: potential predisposing factors
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DOI：
10.1111/j.1439-0507.2005.01124.x
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发表时间：
2005-05-01
期刊：
影响因子：
4.9
通讯作者：
Karamitsos, D
中科院分区：
文献类型：
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作者：
Belazi, M;Velegraki, A;Karamitsos, D
本研究旨在探讨影响2型糖尿病患者口腔念珠菌携带率的潜在因素。128例糖尿病患者(男性68例，女性60例，平均年龄54+/-7岁)与84例(男性44例，女性40例，平均年龄52+/-8岁)健康受试者一起入选。样本是通过擦拭所有参与者的口腔粘膜获得的。通过芽管试验、API32ID系统和玉米粉吐温-80琼脂厚壁孢子产生法对酵母菌进行鉴定。假丝酵母菌从口腔中恢复的占糖尿病组的%，而对照组为40%。白念珠菌是两组中最常见的分离菌种。口干症、假牙、年龄、性别、糖尿病等潜在致病因素对念珠菌口腔携带的影响。都进行了评估。假丝酵母菌的口腔携带。糖尿病患者的口腔念珠菌生长显著高于健康受试者，但似乎口干症、假牙、年龄、性别和血糖控制等参数与糖尿病患者口腔中念珠菌的生长没有直接关系。
This study was designed to investigate the potential factors that influence the prevalence of the oral carriage of Candida species in patients with type II diabetes mellitus. One hundred and twenty-eight diabetic patients (68 males and 60 females, mean age 54 +/- 7 years) were sequentially enrolled along with 84 (44 males and 40 females mean age 52 +/- 8 years) healthy subjects. Samples were obtained by swabbing the oral mucosa of all participants. Yeast isolates were identified by germ tube test, with API 32 ID system, and by chlamydospore production on 'cornmeal' Tween-80 agar. Candida spp. was recovered from the oral cavity of 64% of the diabetic group, in contrast to 40% of the control group. Candida albicans was the most frequently isolated species in both groups. Potential etiologic factors such as xerostomia, dentures, age, gender and diabetes on oral carriage of Candida spp. were evaluated. The oral carriage of Candida spp. was significantly higher in 'diabetic' patients compared with the healthy subjects but it seems that parameters such as xerostomia, dentures, age, gender and glycemic control cannot be directly associated with Candida growth in the oral cavity in the presence of diabetes.