Crystal structure of the open state of the Neisseria gonorrhoeae MtrE outer membrane channel.
Crystal structure of the open state of the Neisseria gonorrhoeae MtrE outer membrane channel.
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DOI：
10.1371/journal.pone.0097475
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Yu EW
中科院分区：
文献类型：
--
作者：
Lei HT;Chou TH;Su CC;Bolla JR;Kumar N;Radhakrishnan A;Long F;Delmar JA;Do SV;Rajashankar KR;Shafer WM;Yu EW
Active efflux of antimicrobial agents is one of the most important strategies used by bacteria to defend against antimicrobial factors present in their environment. Mediating many cases of antibiotic resistance are transmembrane efflux pumps, composed of one or more proteins. The Neisseria gonorrhoeae MtrCDE tripartite multidrug efflux pump, belonging to the hydrophobic and amphiphilic efflux resistance-nodulation-cell division (HAE-RND) family, spans both the inner and outer membranes of N. gonorrhoeae and confers resistance to a variety of antibiotics and toxic compounds. We here describe the crystal structure of N. gonorrhoeae MtrE, the outer membrane component of the MtrCDE tripartite multidrug efflux system. This trimeric MtrE channel forms a vertical tunnel extending down contiguously from the outer membrane surface to the periplasmic end, indicating that our structure of MtrE depicts an open conformational state of this channel.
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影响因子：
3.7
作者：
Kulathila R;Kulathila R;Indic M;van den Berg B
通讯作者：
van den Berg B
DOI：
10.1107/s0907444904019158
发表时间：
2004-12-01
影响因子：
2.2
作者：
Emsley, P;Cowtan, K
通讯作者：
Cowtan, K
影响因子：
16
作者：
Bavro, Vassiliy N.;Pietras, Zbigniew;Furnham, Nicholas;Perez-Cano, Laura;Fernandez-Recio, Juan;Pei, Xue Yuan;Misra, Rajeev;Luisi, Ben
通讯作者：
Luisi, Ben
DOI：
10.1107/s0907444998003254
发表时间：
1998-09-01
期刊：
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
影响因子：
--
作者：
Brunger, AT;Adams, PD;Warren, GL
通讯作者：
Warren, GL
影响因子：
3.2
作者：
Franke, S;Grass, G;Nies, DH
通讯作者：
Nies, DH