Risk of human T-lymphotropic virus type I-associated diseases in Jamaica with common HLA types.
Risk of human T-lymphotropic virus type I-associated diseases in Jamaica with common HLA types.
复制标题
牙买加常见 HLA 类型的人类 T 淋巴细胞病毒 I 型相关疾病的风险。
DOI：
10.1002/ijc.22767
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发表时间：
2007
影响因子：
6.4
通讯作者：
Hisada,Michie
中科院分区：
文献类型：
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作者：
Goedert,JamesJ;Li,Hong-Chuan;Gao,Xiao-Jiang;Chatterjee,Nilanjan;Sonoda,Shunro;Biggar,RobertJ;Cranston,Beverley;Kim,Norma;Carrington,Mary;Morgan,Owen;Hanchard,Barrie;Hisada,Michie
Human T‐lymphotropic virus‐I (HTLV‐I) causes adult T‐cell leukemia/lymphoma (ATL) and HTLV‐associated myelopathy/tropical spastic paraparesis (HAM/TSP). We postulated a higher disease risk for people with common human leukocyte antigen (HLA) types, due to a narrower immune response against viral or neoplastic antigens, compared to people with uncommon types. HLA class‐I (A,B) and class‐II (DRB1, DQB1) allele and haplotype frequencies in 56 ATL patients, 59 HAM/TSP patients and 190 population‐based, asymptomatic HTLV‐I‐infected carriers were compared by logistic regression overall (score test) and with odds ratios (ORs) for common types (prevalence >50% of asymptomatic carriers) and by prevalence quartile. HTLV‐I proviral load between asymptomatic carriers with commonversusuncommon types was compared byt‐test. ATL differed from asymptomatic carriers in overall DQB1 allele and class‐I haplotype frequencies (p≤≤ 0.04). ATL risk was increased significantly with common HLA‐B (OR 2.25, 95% CI 1.19–4.25) and DRB1 (OR 2.11, 95% CI 1.13–3.40) alleles. Higher prevalence HLA‐B alleles were associated with higher ATL risk (OR 1.14 per quartile,ptrend= 0.02). Asymptomatic carriers with common HLA‐B alleles had marginally higher HTLV‐I proviral load (p= 0.057). HAM/TSP risk did not differ consistently with common HLA types. Thus, ATL risk, but not HAM/TSP risk, was increased with higher prevalence HLA‐B alleles. Perhaps breadth of cellular immunity affects risk of this viral leukemia/lymphoma. © 2007 Wiley‐Liss, Inc.
