Reductive stress in young healthy individuals at risk of Alzheimer disease
Reductive stress in young healthy individuals at risk of Alzheimer disease
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DOI：
10.1016/j.freeradbiomed.2013.05.003
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发表时间：
2013-10-01
影响因子：
7.4
通讯作者：
Vina, Jose
中科院分区：
文献类型：
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作者：
Badia, Mari-Carmen;Giraldo, Esther;Vina, Jose
氧化应激是阿尔茨海默病 (AD) 的一个标志，但尚未在有该病风险的年轻健康人群中进行研究。携带 Apo epsilon 4 等位基因是 AD 的主要遗传风险因素。我们观察到，携带至少一种 Apo epsilon 4 等位基因的年轻健康人的淋巴细胞遭受还原应激而非氧化应激，即氧化型谷胱甘肽和 P-p38 水平较低，而参与抗氧化防御的酶表达较高，例如谷氨酰半胱氨酰连接酶和谷胱甘肽过氧化物酶。相反，在成熟的疾病中，情况发生逆转，发生氧化应激，可能是因为刚才提到的抗氧化机制耗尽。这些结果为了解疾病进展的早期事件提供了见解，这可能使我们能够在早期阶段找到 AD 的生物标志物。 (C) 2013 Elsevier Inc. 保留所有权利。
Oxidative stress is a hallmark of Alzheimer disease (AD) but this has not been studied in young healthy persons at risk of the disease. Carrying an Apo epsilon 4 allele is the major genetic risk factor for AD. We have observed that lymphocytes from young, healthy persons carrying at least one Apo epsilon 4 allele suffer from reductive rather than oxidative stress, i.e., lower oxidized glutathione and P-p38 levels and higher expression of enzymes involved in antioxidant defense, such as glutamylcysteinyl ligase and glutathione peroxidase. In contrast, in the full-blown disease, the situation is reversed and oxidative stress occurs, probably because of the exhaustion of the antioxidant mechanisms just mentioned. These results provide insights into the early events of the progression of the disease that may allow us to find biomarkers of AD at its very early stages. (C) 2013 Elsevier Inc. All rights reserved.