OPIOIDS AND SEXUAL-BEHAVIOR IN THE MALE-RAT
OPIOIDS AND SEXUAL-BEHAVIOR IN THE MALE-RAT
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DOI：
10.1016/0091-3057(88)90135-9
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发表时间：
1988-08-01
影响因子：
3.6
通讯作者：
PAREDES, R
中科院分区：
文献类型：
--
作者：
AGMO, A;PAREDES, R
纳洛酮4、16 mg/kg对去势雄性大鼠的交配行为无明显影响。在行为观察前60分钟给予吗啡10 mg/kg，可降低显示性行为的动物比例。2.5或5 mg/kg的剂量减少了第二次射精的潜伏期，而在吗啡10 mg/kg后仍在交配的少数动物显示出第一次射精的潜伏期减少。行为观察前5分钟给予相同剂量的吗啡，产生剂量依赖性的减少安装，插入和射精百分比。然而，那些交配的动物表现出正常的交配行为。在测试前5或60分钟以5 μ g的剂量将D-Ala 2-Met 5脑啡酰胺（DALA）输注到左脑室中没有效果。当在第一次射精后30秒输注肽时，射精次数和射精潜伏期减少。阿片类药物可能促进射精机制，这可能是其奖励性质的结果。此外，在第一次射精后用DALA处理的动物中，第一次和第二次交配系列的射精次数和射精潜伏期相似，而对照动物在第二次射精时这些参数大大降低。内源性阿片样物质的释放可能是射精诱导的亚种性行为便利化的原因。
Naloxone in the doses of 4 or 16 mg/kg failed to affect copulatory behavior of testosterone-treated castrated male rats. Morphine 10 mg/kg, administered 60 min before behavioral observation, reduced the proportion of animals displaying sexual behavior. Doses of 2.5 or 5 mg/kg reduced the latency to the second ejaculation, whereas the few animals still copulating after morphine 10 mg/kg showed a reduced latency to the first ejaculation. The same doses of morphine administered 5 min before behavioral observation produced a dose-dependent reduction of mount, intromission and ejaculation percentages. However, those animals that did copulate showed a normal copulatory behavior. D-Ala2-Met5 enkephalinamide (DALA) infused into the left cerebral ventricle in a dose of 5 .mu.g 5 or 60 min before tests had no effect. When the peptide was infused 30 sec after the first intromission, the number of intromissions as well as the latency to ejaculation were reduced. Opioids may facilitate ejaculatory mechanisms, perhaps as a consequence of their rewarding properties. Moreover, in animals treated with DALA after the first intromission, the number of intromissions and the latency to ejaculation were similar for the first and second copulatory series, while these parameters were much reduced upon the second ejaculation for control animals. It is possible that liberation of endogenous opioids is the cause of ejaculation-induced facilitation of subspecies sexual behavior.