Nighttime snacking reduces whole body fat oxidation and increases LDL cholesterol in healthy young women
Nighttime snacking reduces whole body fat oxidation and increases LDL cholesterol in healthy young women
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DOI：
10.1152/ajpregu.00115.2012
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发表时间：
2013-01-01
影响因子：
2.8
通讯作者：
Ikemoto, Shinji
中科院分区：
文献类型：
--
作者：
Hibi, Masanobu;Masumoto, Ayumi;Ikemoto, Shinji
Hibi M，Masumoto A，Naito Y，Kiuchi K，Yoshimoto Y，MatSumoto M，Katashima M，Oka J，Ikemoto S。夜间零食可以减少健康年轻女性的全身脂肪氧化，增加低密度脂蛋白胆固醇。Am J Physiol Regul Integr Comp Physiol 304：R94-R101,2013.2012年11月28日首次出版；doi：10.1152/ajpregu.00115.2012。-工业化国家肥胖和血脂紊乱的增加可能是由于饮食习惯不规律造成的。很少有研究调查夜间零食对能量代谢的影响。我们观察了连续13天的夜间零食对能量代谢的影响。11名健康女性(平均+/-SD；年龄：23+/-1岁；体重指数：20.6+/-2.6公斤/米(2))参加了这项为期13天的随机交叉试验。受试者在13天的白天(10：00)或夜间(23：00)摄入指定的零食(192.4+/-18.3千卡)。第14天，在不摄入零食的情况下，在呼吸室中测量能量代谢。第15天进行口服葡萄糖耐量试验。与白天进食相比，夜间进食显著减少脂肪氧化(白天进食：52.0+/-13.6g/d；夜间进食：45.8g/-14.0g/d；P=0.02)，并有增加呼吸商的趋势(白天进食：0.878+/-0.022；夜间进食：0.888+/-0.021；P=0.09)。零食摄入量和能量摄入量、体重和能量消耗没有受到影响。夜间零食后总胆固醇和低密度脂蛋白胆固醇显著升高(152+/-26 mg/dl和161+/-29 mg/dl；P=0.03和76+/-20 mg/dl和83+/-24 mg/dl；P+/-0.01)，但不影响糖负荷后的血糖和胰岛素水平。夜间零食增加了总胆固醇和低密度脂蛋白胆固醇，减少了脂肪氧化，这表明夜间进食会改变脂肪代谢，增加肥胖的风险。
Hibi M, Masumoto A, Naito Y, Kiuchi K, Yoshimoto Y, Matsumoto M, Katashima M, Oka J, Ikemoto S. Nighttime snacking reduces whole body fat oxidation and increases LDL cholesterol in healthy young women. Am J Physiol Regul Integr Comp Physiol 304: R94-R101, 2013. First published November 28, 2012; doi:10.1152/ajpregu.00115.2012.-The increase in obesity and lipid disorders in industrialized countries may be due to irregular eating patterns. Few studies have investigated the effects of nighttime snacking on energy metabolism. We examined the effects of nighttime snacking for 13 days on energy metabolism. Eleven healthy women (means +/- SD; age: 23 +/- 1 yr; body mass index: 20.6 +/- 2.6 kg/m(2)) participated in this randomized crossover trial for a 13-day intervention period. Subjects consumed a specified snack (192.4 +/- 18.3 kcal) either during the daytime (10: 00) or the night time (23: 00) for 13 days. On day 14, energy metabolism was measured in a respiratory chamber without snack consumption. An oral glucose tolerance test was performed on day 15. Relative to daytime snacking, nighttime snacking significantly decreased fat oxidation (daytime snacking: 52.0 +/- 13.6 g/day; nighttime snacking: 45.8 +/- 14.0 g/day; P = 0.02) and tended to increase the respiratory quotient (daytime snacking: 0.878 +/- 0.022; nighttime snacking: 0.888 +/- 0.021; P = 0.09). The frequency of snack intake and energy intake, body weight, and energy expenditure were not affected. Total and low-density lipoprotein (LDL) cholesterol significantly increased after nighttime snacking (152 +/- 26 mg/dl and 161 +/- 29 mg/dl; P = 0.03 and 76 +/- 20 mg/dl and 83 +/- 24 mg/dl; P +/- 0.01, respectively), but glucose and insulin levels after the glucose load were not affected. Nighttime snacking increased total and LDL cholesterol and reduced fat oxidation, suggesting that eating at night changes fat metabolism and increases the risk of obesity.