Toward office-based measurement of gastric emptying in symptomatic diabetics using [13C]octanoic acid breath test.
Toward office-based measurement of gastric emptying in symptomatic diabetics using [13C]octanoic acid breath test.
复制标题
使用[13C]辛酸呼气试验对有症状的糖尿病患者进行基于办公室的胃排空测量。
DOI：
10.1111/j.1572-0241.2000.03183.x
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Verlinden,M
中科院分区：
文献类型：
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作者：
Lee,JS;Camilleri,M;Zinsmeister,AR;Burton,DD;Choi,MG;Nair,KS;Verlinden,M
目的：目前通过呼吸试验测量胃排空的方法需要几个小时的采样，对于临床使用太不准确。本研究的目的是开发一种基于办公室的方法，使用[13 C]辛酸呼吸试验来测量糖尿病患者胃中固体的排空。方法：选取22例有症状的糖尿病患者（17例胰岛素依赖型糖尿病患者，5例非胰岛素依赖型糖尿病患者）和6例对照患者，同时采用星形显像法和[13 C]辛酸呼吸试验测定鸡蛋粉（420 kcal）胃排空量。传统的（非线性）方法用于星形图和[13 C]辛酸呼气试验排空和广义线性回归方法预测星形图半衰期（t1 /2），使用前3小时获得的4个呼吸样本。结果：尽管进行了8小时的呼吸采样，使用传统方法估计的t1 /2与星形图值显着不同（Δt 1/2：中位数，113分钟；范围，19-282分钟）。广义线性模型（使用基线、30、120或150分钟的样本）预测的科学图t - LAG和t 1/2比传统方法更准确；差异的平均标准偏差分别为16和27分钟。呼吸测试正确评估了22例患者中21例正常或长时间排空。结论：[13 C]辛酸呼气试验可简化为测量胃t - LAG和t1 /2，有望正确识别有症状的糖尿病患者正常的t1 /2。该模型的进一步完善需要包括对t1 /2明显延迟的患者的研究。
OBJECTIVE:Current methods for measuring gastric emptying by breath test require sampling over several hours and are too inaccurate for clinical use. The aim of this study was to develop an office-based method for measuring gastric emptying of solids in patients with diabetes using a [13 C] octanoic acid breath test.METHODS:In 22 symptomatic diabetic patients (17 insulin-dependent diabetes, 5 non–insulin-dependent diabetes) and 6 controls, we simultaneously measured gastric emptying of an egg meal (420 kcal) by scintigraphy and [13 C] octanoic acid breath test. Conventional (nonlinear) methods for scintigraphic and [13 C] octanoic acid breath test emptying and generalized linear regression method to predict scintigraphic half-life (t 1/2) using four breath samples obtained during the first 3 h.RESULTS:Despite 8 h of breath sampling, the t 1/2 estimate using the conventional method was markedly different from the scintigraphic value (Δt 1/2: median, 113 min; range, 19–282 min). The generalized linear model (using samples at baseline, 30, and 120 or 150 min) yielded predicted scintigraphic t LAG and t 1/2 that were more accurate than the conventional method; mean standard deviations of differences were 16 and 27 min, respectively. Breath test correctly assessed normal or prolonged emptying in 21 of 22 patients.CONCLUSIONS:The [13 C] octanoic acid breath test can be simplified to measure gastric t LAG and t 1/2 and can be expected to correctly identify normal t 1/2 in symptomatic diabetics. Further refinement of the model will need to include studies of patients with markedly delayed t 1/2.