Antigenic drift between the haemagglutinin of the Hong Kong influenza strains A/Aichi/2/68 and A/Victoria/3/75
Antigenic drift between the haemagglutinin of the Hong Kong influenza strains A/Aichi/2/68 and A/Victoria/3/75
复制标题
香港流感病毒株A/Aichi/2/68和A/Victoria/3/75的血凝素之间的抗原漂移
作者：
M. Verhoeyen;R. Fang;W. Jou;R. Devos;D. Huylebroeck;E. Saman;W. Fiers
将编码甲型流感病毒/Aichi/2/68血凝素蛋白的基因的DNA拷贝克隆到质粒pBR 322中，并测定完整的核苷酸序列。将该一级结构和推导的氨基酸序列与属于相同亚型（H3）和不同亚型（人源（H2）和禽源（Hav 1））的菌株的血凝素基因和蛋白质进行比较，进一步证明了在分子水平上病毒抗原变异的两种独立模式-漂移和转移。
A DNA copy of the gene coding for the influenza A/Aichi/2/68 haemagglutinin protein was cloned in the plasmid pBR322 and the complete nucleotide sequence determined. Comparison of this primary structure and the deduced amino acid sequence with the haemagglutinin gene and protein of strains belonging to the same (H3) subtype and to different subtypes, of both human (H2) and avian (Hav1) origin, documents further at the molecular level the two independent modes of antigenic variation of the virus—drift and shift.