Actin, microtubules and focal adhesion dynamics during cell migration
Actin, microtubules and focal adhesion dynamics during cell migration
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DOI：
10.1016/s1357-2725(02)00071-7
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发表时间：
2003-01-01
影响因子：
4
通讯作者：
Imhof, BA
中科院分区：
文献类型：
--
作者：
Wehrle-Haller, B;Imhof, BA
细胞迁移是一种复杂的细胞行为，是由肌动蛋白细胞骨架的协调变化和细胞-基质粘附位点的受控形成和分散引起的。虽然肌动蛋白细胞骨架在细胞前部提供驱动力，但微管网络在协调后部收缩中承担调节功能。迁移细胞内的极性进一步突出表现为前部粘着斑的静止行为和尾部粘着斑的滑动。在这里，我们讨论的串扰的肌动蛋白细胞骨架与微管网络和潜在的机制，控制在细胞迁移过程中的粘着斑网站的差异行为。(C)2002爱思唯尔科技有限公司。保留所有权利。
Cell migration is a complex cellular behavior that results from the coordinated changes in the actin cytoskeleton and the controlled formation and dispersal of cell-substrate adhesion sites. While the actin cytoskeleton provides the driving force at the cell front, the microtubule network assumes a regulatory function in coordinating rear retraction. The polarity within migrating cells is further highlighted by the stationary behavior of focal adhesions in the front and their sliding in trailing ends. We discuss here the cross-talk of the actin cytoskeleton with the microtubule network and the potential mechanisms that control the differential behavior of focal adhesions sites during cell migration. (C) 2002 Elsevier Science Ltd. All rights reserved.