Ferritin in the coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis.
Ferritin in the coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis.
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2019 年冠状病毒病 (COVID-19) 中的铁蛋白：系统评价和荟萃分析
DOI：
10.1002/jcla.23618
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发表时间：
2020-10
影响因子：
2.7
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Cheng L;Li H;Li L;Liu C;Yan S;Chen H;Li Y
2019冠状病毒病（COVID-19）已迅速发展为大流行病。在重度COVID-19患者中发现了由于细胞因子风暴和继发性噬血细胞性淋巴组织细胞增多症导致的铁蛋白水平升高。因此，本研究的目的是确定铁蛋白在COVID-19中的作用。从PubMed、EMBASE、CNKI、SinoMed和WANFANG收集了研究COVID-19中铁蛋白的研究。进行了一项Meta分析，以比较不同患者组之间的铁蛋白水平：非幸存者与幸存者;较严重与较不严重;合并症与无合并症; ICU与非ICU;机械通气与无机械通气。本次Meta分析共纳入了52条记录，涉及2019年12月25日至2020年6月1日期间的10614例COVID-19确诊患者，定性综合纳入了18项研究。与非重度患者相比，重度患者的铁蛋白水平显著升高[WMD 397.77（95% CI 306.51 - 489.02），P < .001]。非存活者的铁蛋白水平显著高于存活者[WMD 677.17（95% CI 391.01 - 963.33），P < .001]。有一种或多种合并症包括糖尿病、血栓性并发症和癌症的患者铁蛋白水平显著高于无合并症的患者（P <0.01）。严重急性肝损伤与高水平铁蛋白显著相关，其水平与重症支持治疗相关，包括ICU转移和机械通气。铁蛋白与不良预后相关，可以预测COVID-19患者的恶化。血清铁蛋白是COVID-19中有价值的生物标志物。事实上，这项Meta分析揭示了血清铁蛋白水平与COVID-19患者的临床特征（包括疾病严重程度、死亡率、合并症和某些治疗）之间的相关性。因此，铁蛋白与不良预后相关，并可预测COVID-19患者的恶化。
The coronavirus disease 2019 (COVID‐19) has rapidly developed into a pandemic. Increased levels of ferritin due to cytokine storm and secondary hemophagocytic lymphohistiocytosis were found in severe COVID‐19 patients. Therefore, the aim of this study was to determine the role of ferritin in COVID‐19. Studies investigating ferritin in COVID‐19 were collected from PubMed, EMBASE, CNKI, SinoMed, and WANFANG. A meta‐analysis was performed to compare the ferritin level between different patient groups: non‐survivors versus survivors; more severe versus less severe; with comorbidity versus without comorbidity; ICU versus non‐ICU; with mechanical ventilation versus without mechanical ventilation. A total of 52 records involving 10 614 COVID‐19‐confirmed patients between December 25, 2019, and June 1, 2020, were included in this meta‐analysis, and 18 studies were included in the qualitative synthesis. The ferritin level was significantly increased in severe patients compared with the level in non‐severe patients [WMD 397.77 (95% CI 306.51‐489.02), P < .001]. Non‐survivors had a significantly higher ferritin level compared with the one in survivors [WMD 677.17 (95% CI 391.01‐963.33), P < .001]. Patients with one or more comorbidities including diabetes, thrombotic complication, and cancer had significantly higher levels of ferritin than those without (P < .01). Severe acute liver injury was significantly associated with high levels of ferritin, and its level was associated with intensive supportive care, including ICU transfer and mechanical ventilation. Ferritin was associated with poor prognosis and could predict the worsening of COVID‐19 patients. Serum ferritin resulted as a valuable biomarker in COVID‐19. Indeed, this meta‐analysis revealed the association between the serum ferritin level and clinical characteristics of COVID‐19 patients including disease severity, mortality, comorbidities, and certain treatment. Thus, ferritin was associated with poor prognosis and could predict the worsening of COVID‐19 patients.
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DOI：
10.1097/pcc.0000000000001029
发表时间：
2017-02
期刊：
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
影响因子：
--
作者：
Carcillo JA;Sward K;Halstead ES;Telford R;Jimenez-Bacardi A;Shakoory B;Simon D;Hall M;Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network Investigators
通讯作者：
Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network Investigators
影响因子：
3.9
作者：
Bellmann-Weiler, Rosa;Lanser, Lukas;Weiss, Guenter
通讯作者：
Weiss, Guenter
影响因子：
6.8
作者：
Bonetti, Graziella;Manelli, Filippo;Lippi, Giuseppe
通讯作者：
Lippi, Giuseppe
影响因子：
14.2
作者：
Cugno, Massimo;Meroni, Pier Luigi;Peyvandi, Flora
通讯作者：
Peyvandi, Flora
影响因子：
15.9
作者：
Chen, Guang;Wu, Di;Ning, Qin
通讯作者：
Ning, Qin