The Synergistic Effect of Proteins and Reactive Oxygen Species on Electrochemical Behaviour of 316L Stainless Steel for Biomedical Applications
The Synergistic Effect of Proteins and Reactive Oxygen Species on Electrochemical Behaviour of 316L Stainless Steel for Biomedical Applications
复制标题
蛋白质和活性氧对生物医学应用 316L 不锈钢电化学行为的协同效应
DOI：
10.1088/1757-899x/374/1/012058
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
V. Dumitraşcu
中科院分区：
文献类型：
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作者：
N. Simionescu;L. Benea;V. Dumitraşcu
不锈钢，特别是316L型不锈钢，因其良好的生物相容性、低廉的价格、优异的耐腐蚀性、可获得性、易于加工和高强度，是生物医学领域应用最广泛的金属生物材料。由于这些良好的性能，316L不锈钢已成为最具吸引力的牙科植入物、支架和骨科植入物的生物材料。然而，人体内的植入材料会受到其他分子的作用，包括细菌和免疫细胞产生的蛋白质(如白蛋白)和活性氧物种(如过氧化氢-过氧化氢)。在文献中，很少有关于蛋白质和活性氧物种对316L不锈钢作为种植材料的影响的研究，目前仍不清楚。在口腔或身体环境中使用金属生物材料时，耐腐蚀性是第一个标准。本研究的目的是研究蛋白质(白蛋白)和活性氧物种(H_2O_2)的组合影响，同时考虑这两个因素对316L不锈钢的协同作用。白蛋白存在于植入物附近的体内，在炎症过程中也可能出现活性氧物种。研究表明，白蛋白和活性物种的存在影响了316L不锈钢在生物溶液中的耐蚀性。本研究采用开路电位、交流阻抗谱等电化学方法对316L不锈钢的腐蚀行为进行了研究。结果表明，电化学测试结果与腐蚀前后的显微照片吻合较好。白蛋白和活性氧物种对316L不锈钢的行为有影响。
The stainless steels, especially 316L type is the most used metallic biomaterials for biomedical applications due to their good biocompatibility, low price, excellent corrosion resistance, availability, easy processing and high strength. Due to these favorable properties 316L stainless steel has become the most attractive biomaterial for dental implants, stents and orthopedic implants. However an implant material in the human body is exposed to an action effect of other molecules, including proteins (such as albumin) and reactive oxygen species (such as hydrogen peroxide - H2O2) produced by bacteria and immune cells. In the literature there are few studies to follow the effect of proteins and reactive oxygen species on 316L stainless steel used as implant material and are still unclear. The degree of corrosion resistance is the first criterion in the use of a metallic biomaterial in the oral or body environment. The aim of this research work is to investigate the influence of proteins (albumin) and reactive oxygen species (H2O2) in combination, taking into account the synergistic effect of these two factors on 316L stainless steel. Albumin is present in the body near implants and reactive oxygen species could appear in inflammatory processes as well. The study shows that the presence of albumin and reactive species influences the corrosion resistance of 316L stainless steel in biological solutions. In this research work the corrosion behavior of 316L stainless steel is analyzed by electrochemical methods such as: open circuit potential (OCP), Electrochemical Impedance Spectroscopy (EIS). It was found that, the electrochemical results are in a good agreement with micro photographs taken before and after corrosion assays. The albumin and reactive oxygen species have influence on 316L stainless steel behavior.