Optical clearing of human dura mater
Optical clearing of human dura mater
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DOI：
10.1134/1.1890530
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发表时间：
2005-03-01
影响因子：
0.6
通讯作者：
Tuchin, VV
中科院分区：
文献类型：
--
作者：
Genina, ÉA;Bashkatov, AN;Tuchin, VV
本文研究了浓度为0.16 μ g/ml的甘露醇水溶液在400-700 nm光谱范围内对人硬脑膜光学参数的影响。甘露醇扩散到组织中导致结构形成元素（胶原纤维）和硬脑膜基质（间质液）的折射率部分匹配。结果，在所研究的整个光谱范围内生物组织的光散射平均降低了1.5-2倍。研究表明，生物组织的浸泡会导致血液吸收带范围内硬脑膜的吸收减少1.2-1.6倍。所提出的结果可能被证明是有用的激光治疗和脑疾病的光学诊断。(C)Pleiades Publishing，Inc.
The changes in the optical parameters of the human dura mater in the spectral range 400-700 nm caused by the action of an aqueous solution of mannitol with a concentration of 0.16 g/ml are studied in vitro. The diffusion of mannitol into the tissue leads to a partial matching between the refractive indices of the structure-forming elements (the collagen fibrils) and the base substance of the dura mater (the interstitial fluid). As a result, the light scattering by the biological tissue in the entire spectral range under study is decreased, on the average, by a factor of 1.5-2. The immersion of the biological tissue is shown to cause a decrease in the absorption of the dura mater in the range of the blood absorption bands by a factor of 1.2-1.6. The results presented may prove to be useful in the laser therapy and optical diagnostics of brain diseases. (C) 2005 Pleiades Publishing, Inc.