Amygdaloid complex lesions differentially affect retention of tasks using appetitive and aversive reinforcement.
Amygdaloid complex lesions differentially affect retention of tasks using appetitive and aversive reinforcement.
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杏仁核复合体损伤通过食欲和厌恶强化对任务的保留产生不同的影响。
DOI：
10.1037//0735-7044.104.4.532
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发表时间：
1990
影响因子：
1.9
通讯作者：
McGaugh,JL
中科院分区：
文献类型：
--
作者：
Cahill,L;McGaugh,JL
杏仁体复合体（AC）参与刺激-奖赏关联的形成的假设进行了研究。一系列实验（1A-1C）直接比较了损伤（通过注射兴奋性毒素N-甲基-D-天冬氨酸产生）对大鼠单次食欲和单次厌恶学习的影响。实验1A和1B，其中使用不同程度的强化，发现没有影响的病变的食欲任务，而收购的厌恶任务显着受损。这种损害取决于所使用的厌恶性强化的性质：当使用高度厌恶性刺激（电击脚）时会出现损害，但当使用较不厌恶性刺激（0.2%奎宁溶液）时则不会。对照实验表明，病变的影响不是由于对足电击的敏感性降低。在实验2中，一种新的气味条件反射任务进一步研究了AC病变对食欲和厌恶刺激强化协会收购的影响。在实验1中，AC病变损害学习的厌恶协会，但没有显着影响的食欲协会。有人认为，虽然AC可能参与某些类型的食欲奖励的学习，AC病变的差异性影响的研究结果，对厌恶奖励的学习建议在学习中的作用超出了刺激强化协会的形成。
The hypothesis that the amgydaloid complex (AC) is involved in the formation of stimulus–reward associations was examined. A series of experiments (1A–1C) directly compared the effects of lesions (produced by injection of the excitotoxin N-methyl-D-aspartic acid) on 1-trial appetitive and 1-trial aversive learning in rats. Experiments 1A and 1B, which used different degrees of reinforcement, revealed no effect of lesions on the appetitive task, whereas acquisition of the aversive task was significantly impaired. This impairment depended on the nature of the aversive reinforcement used: Impairment was seen when a highly aversive stimulus (footshock) was used but not when a less aversive stimulus (0.2% quinine solution) was used. Control experiments indicated that the effect of lesions was not due to reduced sensitivity to the footshock. In Experiment 2, a novel odor conditioning task examined further the effect of AC lesions on the acquisition of appetitive and aversive stimulus–reinforcement associations. As in Experiment 1, the AC lesions impaired learning of the aversive association but did not significantly influence the appetitive association. It is argued that, although the AC may be involved in some types of appetitively rewarded learning, the findings of a differential effect of AC lesions on aversively rewarded learning suggest a role in learning beyond the formation of stimulus–reinforcement associations.
DOI：
10.1007/978-1-4612-3500-2
发表时间：
1989
期刊：
The American psychologist
影响因子：
--
作者：
P. Solomon;G. Goethals;C. M. Kelley;R. Stephens
通讯作者：
R. Stephens
杏仁核的神经生物学
DOI：
--
发表时间：
1972
期刊：
Advances in behavioral biology
影响因子：
--
作者：
B. Eleftheriou
通讯作者：
B. Eleftheriou
记忆的生理基础。
影响因子：
24.8
作者：
J. Deutsch
通讯作者：
J. Deutsch