CuBr-Catalyzed Coupling of N-Tosylhydrazones and Terminal Alkynes: Synthesis of Benzofurans and Indoles.
CuBr-Catalyzed Coupling of N-Tosylhydrazones and Terminal Alkynes: Synthesis of Benzofurans and Indoles.
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DOI：
10.1021/ol103009n
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发表时间：
2011-01
期刊：
影响因子：
5.2
通讯作者：
Lei Zhou;Yi Shi;Q. Xiao;Yizhou Liu;F. Ye;Yan Zhang;J. Wang
中科院分区：
文献类型：
--
作者：
Lei Zhou;Yi Shi;Q. Xiao;Yizhou Liu;F. Ye;Yan Zhang;J. Wang
开发了一种通过无配体溴化铜催化末端炔与邻羟基或邻氨基苯甲醛衍生的 N-甲苯磺酰腙的偶联/环化来合成苯并呋喃或吲哚的新方法。发现了多种能够耐受反应条件的官能团。
A new method for the synthesis of benzofurans or indoles via ligand-free CuBr-catalyzed coupling/cyclization of terminal alkynes with N-tosylhydrazones derived from o-hydroxy- or o-aminobenzaldehydes has been developed. A wide range of functional groups were found that are able to tolerate the reaction conditions.