Collective cell migration of epithelial cells driven by chiral torque generation
Collective cell migration of epithelial cells driven by chiral torque generation
复制标题
手性扭矩产生驱动上皮细胞的集体细胞迁移
DOI：
10.1103/physrevresearch.2.043326
复制
发表时间：
2020
影响因子：
4.2
通讯作者：
Shibata Tatsuo
中科院分区：
文献类型：
--
作者：
Yamamoto Takaki;Hiraiwa Tetsuya;Shibata Tatsuo
各种多细胞组织显示手性形态。实验研究表明，这可能源于单个细胞的手性。然而，还没有理论被提出来连接细胞手性扭矩和多细胞手性形态发生。我们提出了一个融合的组织动力学与细胞手征扭矩模型。我们发现，细胞迁移的细胞手性扭矩的梯度下单向。虽然迁移速度根据组织的机械参数而变化，但它仅由融合组织中液体到固体转变的结构序参数确定。
Various multicellular tissues show chiral morphology. Experimental studies have suggested that this can originate from the chirality of individual cells. However, no theory has been proposed to connect the cellular chiral torque and multicellular chiral morphogenesis. We propose a model of confluent tissue dynamics with cellular chiral torque. We found that cells migrate unidirectionally under a gradient of cellular chiral torque. While the migration speed varies depending on the tissue's mechanical parameters, it is determined solely by a structural order parameter for the liquid-to-solid transition in confluent tissues.