PROFOUND BUT REVERSIBLE MYOCARDIAL DEPRESSION IN PATIENTS WITH SEPTIC SHOCK
PROFOUND BUT REVERSIBLE MYOCARDIAL DEPRESSION IN PATIENTS WITH SEPTIC SHOCK
复制标题
DOI：
10.7326/0003-4819-100-4-483
复制
发表时间：
1984-01-01
影响因子：
39.2
通讯作者：
PARRILLO, JE
中科院分区：
文献类型：
--
作者：
PARKER, MM;SHELHAMER, JH;PARRILLO, JE
为探讨心功能在感染性休克中的作用，对20例感染性休克患者进行了放射性核素血管造影和血流动力学评价。尽管所有患者的心脏指数均正常或升高，但10例患者的射血分数中度至重度降低，数值低于0.40。20名患者中有13名幸存下来。13例存活者中10例存活，7例死亡者无1例存活，初始射血分数小于0.40（P < 0.005）。存活者的平均初始射血分数为0.32 ± 0.05。0.04并且他们的平均心室容积、收缩期心室容积和舒张末期心室容积显著增加，每搏输出量正常。存活者的连续扫描显示，在休克发生后10天，射血分数和心室容积逐渐恢复正常。非幸存者的初始射血分数和心室容积正常，在系列研究中没有变化。
To characterize the role of cardiac function in septic shock, serial radionuclide cineangiographic and hemodynamic evaluations were done on 20 patients with documented septic shock. Although all patients had a normal or elevated cardiac index, 10 patients had moderate to severe depression of their ejection fraction with values below 0.40. Thirteen of 20 patients survived their episode. Paradoxically, 10 of 13 survivors, but none of the 7 nonsurvivors, and an initial ejection fraction less than 0.40 (P < 0.005). The mean initial ejection fraction for the survivors was 0.32 .+-. 0.04 and their mean and systolic and end diastolic ventricular volumes were substantially increased with a normal stroke volume. The survivors'' serial scans showed a gradual return to normal ejection fraction and ventricular volume by 10 days after the onset of shock. Nonsurvivors had normal initial ejection fractions and ventricular volumes that did not change during serial studies.