Heparan sulfate: a ubiquitous glycosaminoglycan with multiple roles in immunity.
Heparan sulfate: a ubiquitous glycosaminoglycan with multiple roles in immunity.
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DOI：
10.3389/fimmu.2013.00470
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发表时间：
2013-12-18
影响因子：
7.3
通讯作者：
Parish CR
中科院分区：
文献类型：
--
作者：
Simon Davis DA;Parish CR
硫酸乙酰肝素（HS）是一种高度酸性的线性多糖，具有非常可变的结构。它广泛表达于细胞表面和哺乳动物组织的细胞外基质和基底膜中。HS是一种合成的蛋白多糖，与各种核心蛋白结合形成HS-蛋白多糖，能够与各种多肽相互作用，发挥多种功能。事实上，表达肝素/HS结合基序并与免疫系统相关的哺乳动物蛋白的生物信息学分析鉴定了235种候选蛋白，大多数具有细胞内位置。这个简单的分析表明，事实上，HS可能与免疫系统中比以前意识到的更多的成分相互作用。许多研究也直接证明了HS在免疫系统中发挥着多种突出的功能作用，本文对此进行了简要综述。特别是，该分子已被证明可调节白细胞发育、白细胞迁移、免疫激活和炎症过程。
Heparan sulfate (HS) is a highly acidic linear polysaccharide with a very variable structure. It is ubiquitously expressed on cell surfaces and in the extracellular matrix and basement membrane of mammalian tissues. Synthesized attached to various core proteins to form HS-proteoglycans, HS is capable of interacting with various polypeptides and exerting diverse functions. In fact, a bioinformatics analysis of mammalian proteins that express a heparin/HS-binding motif and are associated with the immune system identified 235 candidate proteins, the majority having an intracellular location. This simple analysis suggests that HS may, in fact, interact with many more components of the immune system than previously realized. Numerous studies have also directly demonstrated that HS plays multiple prominent functional roles in the immune system that are briefly reviewed in this article. In particular, the molecule has been shown to regulate leukocyte development, leukocyte migration, immune activation, and inflammatory processes.