The relationship of neuropsychological abilities to specific domains of functional capacity in older schizophrenia patients
The relationship of neuropsychological abilities to specific domains of functional capacity in older schizophrenia patients
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DOI：
10.1016/s0006-3223(02)01476-2
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发表时间：
2003-03-01
影响因子：
10.6
通讯作者：
Jeste, DV
中科院分区：
文献类型：
--
作者：
Evans, JD;Heaton, RK;Jeste, DV
背景资料：本研究旨在确定认知措施的相对重要性，在预测各领域的日常功能能力在老年门诊schizophrenia.Methods：93精神科门诊诊断为精神分裂症和情感障碍进行了全面的神经精神评估，包括神经心理学测试和临床评级的精神病理学。结果：除简单进食行为、时间定向和仪容整洁外，神经心理学表现对大多数日常生活活动（ADL/IADL）均有显著预测作用。较低的教育水平和阴性症状也与较差的功能能力有关，而阳性症状和抑郁情绪则与之无关。认知功能的措施占更多的功能能力比精神症状的评级的变化，和多元回归分析表明，神经心理性能的预测功能能力，超过和以上的临床症状。没有特定的认知领域的功能capability.Conclusions的特定领域的差异预测：神经认知能力的功能能力比水平的临床症状，但是，这些能力没有特定的预测功能。这与精神分裂症中相对普遍的、相互关联的认知障碍和日常功能的多个确定领域的研究结果一致。
Background: This study sought to determine the relative importance of cognitive measures in predicting various domains of everyday functional capacity in older outpatients with schizophrenia.Methods: Ninety-three psychiatry outpatients with diagnoses of schizophrenia and schizoaffective disorders underwent a comprehensive neuropsychiatric evaluation, including neuropsychological testing and clinical ratings of psychopathology. Functional capacity was assessed with the Direct Assessment of Functional Status, a performance measure of basic and instrumental activities of daily living (ADLs/IADLs).Results: Neuropsychological performance significantly predicted most ADLs/IADLs measured, except simple eating behaviors, time orientation, and grooming. Lower educational level and negative symptoms also were associated with worse functional capacity, whereas positive symptoms and depressed mood were not. Measures of cognitive functioning accounted for more variance in functional capacity than did psychiatric ratings of symptoms, and multiple regression analyses demonstrated that neuropsychological performance was predictive of functional capacity, over and above clinical symptoms. No specific cognitive domains were differentially predictive of specific domains of functional capacity.Conclusions: Neurocognitive abilities were more predictive of functional capacity than level of clinical symptoms; however, these abilities were not specific predictors of functioning. This is consistent with findings of relatively generalized, intercorrelated cognitive impairment in schizophrenia and multiply determined domains of everyday functioning.