Isoflavonoids with antiestrogenic activity from Millettia pachycarpa
Isoflavonoids with antiestrogenic activity from Millettia pachycarpa
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DOI：
10.1021/np050341w
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发表时间：
2006-01-01
影响因子：
5.1
通讯作者：
Furukawa, H
中科院分区：
文献类型：
--
作者：
Ito, C;Itoigawa, M;Furukawa, H
从厚果崖豆藤（Millettia pachycarpa）叶中分得3个新化合物，分别命名为崖豆藤素G（1）、H（2）和糠藤素B（3）。通过波谱分析鉴定了它们的结构。在酵母双杂交试验的抗雌激素活性，这些化合物进行了检查，并显示与4-羟基他莫昔芬。
Three new isoflavonoids, named millewanins G (1) and H (2) and furowanin B (3), were isolated from the leaves of Millettia pachycarpa. Their structures were elucidated on the basis of spectroscopic analyses. The antiestrogenic activity in the yeast two-hybrid assay of these isoflavonoids was examined and shown to be comparable with that of 4-hydroxytamoxifen.