Dynamic combinatorial libraries constructed on polymer scaffolds
Dynamic combinatorial libraries constructed on polymer scaffolds
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DOI：
10.1021/ol8011309
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发表时间：
2008-08-07
期刊：
影响因子：
5.2
通讯作者：
Fulton, David A.
中科院分区：
文献类型：
--
作者：
Fulton, David A.
通过可逆的腙键将酰肼接枝到聚乙烯基苯甲醛支架上来制备官能化聚合物。这些连接的动态性质允许官能化聚合物交换和重排它们的附属物，并且所得的聚合物混合物可以被认为是在聚合物支架上构建的动态组合文库。这些功能化的聚合物的动态性质被证明。
Functionalized polymers were prepared by grafting acylhydrazides onto a polyvinylbenzaldehyde scaffold through reversible hydrazone linkages. The dynamic nature of these linkages allows the functionalized polymers to exchange and reshuffle their appendages, and the resultant mixture of polymers can be considered as a dynamic combinatorial library constructed upon a polymer scaffold. The dynamic nature of these functionalized polymers was demonstrated.