Towards conformationally-locked difluorosugar analogues: an unexpected sense of dihydroxylation.
Towards conformationally-locked difluorosugar analogues: an unexpected sense of dihydroxylation.
复制标题
走向构象锁定的二氟糖类似物：意想不到的二羟基化感觉。
作者：
J. Fawcett;Gerry A. Griffiths;J. Percy;Stéphane Pintat;Clive A. Smith;N. Spencer;E. Uneyama
利用RCM合成的二氟环辛烯酮可以作为模板，用于立体选择性氧化转化为跨环反应的产物，得到构象锁定的2-脱氧-2，2-二氟糖类似物，其中C-2和C-3羟基之间具有不同的立体化学关系。
Difluorinated cyclooctenones, synthesised using RCM, can be used as templates for stereoselective oxidative transformations to products that undergo transannular reactions to afford conformationally-locked analogues of 2-deoxy-2,2-difluorosugars with different stereochemical relationships between the C-2 and C-3 hydroxyl groups.