The EUropean Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI): Incidence and First-Episode Case-Control Programme
The EUropean Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI): Incidence and First-Episode Case-Control Programme
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DOI：
10.1007/s00127-020-01831-x
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发表时间：
2020-05-01
影响因子：
4.4
通讯作者：
Morgan, Craig
中科院分区：
文献类型：
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作者：
Gayer-Anderson, Charlotte;Jongsma, Hannah E.;Morgan, Craig
目的：研究基因-环境相互作用的欧洲国家精神分裂症网络网络（EU-GEI）研究包含了无与伦比的丰富的综合数据，允许测试以下假设：(1)国家内部和国家之间发病率的变化，包括城市化和少数民族群体；(2)多种环境和遗传风险因素在精神障碍发展中的作用及其相互作用。方法2010年至2015年间，我们在6个国家（英国、荷兰、法国、西班牙、意大利和巴西）的17个地点，在1290万人年的风险中发现了2774例精神障碍事件。在2774例病例中，对1130例病例进行了详细评估，并形成病例样本进行病例对照分析。在所有站点中，招募并评估了1497名对照者。我们收集了广泛的暴露和结果数据，包括人口统计学、临床（如病前调整）、社会（如童年和成人逆境、大麻使用、移民、歧视）、认知（如智商、面部情绪处理、归因偏差）和生物学（通过血液样本/脸颊拭子获取的DNA）。我们描述了研究的方法和一些描述性结果，包括队列的代表性。结论：这一资源构成了迄今为止进行的最大、最广泛的精神病发病率和病例对照研究。
Purpose The EUropean Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) study contains an unparalleled wealth of comprehensive data that allows for testing hypotheses about (1) variations in incidence within and between countries, including by urbanicity and minority ethnic groups; and (2) the role of multiple environmental and genetic risk factors, and their interactions, in the development of psychotic disorders. Methods Between 2010 and 2015, we identified 2774 incident cases of psychotic disorders during 12.9 million person-years at risk, across 17 sites in 6 countries (UK, The Netherlands, France, Spain, Italy, and Brazil). Of the 2774 incident cases, 1130 cases were assessed in detail and form the case sample for case-control analyses. Across all sites, 1497 controls were recruited and assessed. We collected data on an extensive range of exposures and outcomes, including demographic, clinical (e.g. premorbid adjustment), social (e.g. childhood and adult adversity, cannabis use, migration, discrimination), cognitive (e.g. IQ, facial affect processing, attributional biases), and biological (DNA via blood sample/cheek swab). We describe the methodology of the study and some descriptive results, including representativeness of the cohort. Conclusions This resource constitutes the largest and most extensive incidence and case-control study of psychosis ever conducted.