Multiple Myeloma: Diagnosis and Treatment.
Multiple Myeloma: Diagnosis and Treatment.
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多发性骨髓瘤：诊断和治疗。
DOI：
10.1016/j.mayocp.2015.11.007
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发表时间：
2016-01
影响因子：
8.9
通讯作者：
Kumar S
中科院分区：
文献类型：
--
作者：
Rajkumar SV;Kumar S
多发性骨髓瘤（MM）的诊断和治疗在过去十年中发生了巨大变化。已更新疾病定义，以允许高度特异性的生物标志物，除了确定终末器官损伤的标志物。对分期系统进行了修订，以联合收割机肿瘤负荷和疾病生物学的测量。治疗的进步已经导致总生存期的显著改善。最近几年推出的新药包括卡非佐米、泊马度胺和帕比司他。此外，单克隆抗体如埃罗妥珠单抗和达雷妥尤单抗已显示出有前景的临床活性。在这篇综述中，我们概述了目前的诊断方法，预后和管理的MM。
The diagnosis and treatment of multiple myeloma (MM) has changed dramatically in the last decade. The disease definition has been updated to allow highly specific biomarkers in addition to established markers of end-organ damage. The staging system has been revised to combine both measures of tumor burden and disease biology. Advances in therapy have resulted in a significant improvement of overall survival. New drugs introduced in the last few years include carfilzomib, pomalidomide, and panobinostat. In addition, monoclonal antibodies such as elotuzumab and daratumumab have shown promising clinical activity. In this review, we outline the current approach to diagnosis, prognosis, and management of MM.