Progressive Chagas' cardiomyopathy is associated with low selenium levels
Progressive Chagas' cardiomyopathy is associated with low selenium levels
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DOI：
10.4269/ajtmh.2002.66.706
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发表时间：
2002-06-01
影响因子：
3.3
通讯作者：
Araújo-Jorge, TC
中科院分区：
文献类型：
--
作者：
Rivera, MT;De Souza, AP;Araújo-Jorge, TC
硒 (Se) 缺乏与某些心肌病有关。其状态是在来自巴西 2 个地区（里约热内卢和贝洛奥里藏特）的 170 名慢性恰加斯病患者中确定的，临床上分为以下几组：不确定或无症状 (IND)；心脏无症状（CARDa）；有中度至重度心功能障碍的心脏症状 (CARDb)；和健康成人（HA），用于比较。在大多数 HA 中，硒水平正常，排除整体硒缺乏的情况。 CARDb 患者中的 Se 显着低于 HA、IND 或 CARDa 患者。这与谷胱甘肽过氧化物酶活性的伴随降低无关。促甲状腺激素正常，排除碘缺乏。 Se 与心室射血分数呈显着正相关（通过超声心动图评估）。患有急性恰加斯病的无症状儿童的硒浓度正常，5 例非感染性心肌病病例的硒浓度也正常。 10 名患有消化巨综合征的恰加斯病患者中，有 6 名发现了低硒。因此，恰加斯病患者体内硒的减少似乎是克氏锥虫感染的生物学标志，并且与病理进展有关。
Selenium (Se) deficiency is linked with some cardiomyopathies. Its status was determined in 170 patients with chronic Chagas' disease from 2 Brazilian regions (Rio de Janeiro and Belo Horizonte), clinically stratified into groups as follows: indeterminate or asymptomatic (IND); cardiac asymptomatic (CARDa); cardiac symptomatic with moderate to severe heart dysfunction (CARDb); and healthy adults (HA), used for comparison. In most HA, Se levels were normal, excluding an overall Se deficiency. Se was significantly lower in CARDb than in HA, IND, or CARDa patients. This was not associated with a concomitant decrease in activity of glutathione peroxidase. Thyrotropin was normal, excluding iodine deficiency. Se correlated positive and significantly with ventricular ejection fraction (assessed via echocardiography). Asymptomatic children with acute Chagas' disease had normal Se as well as 5 noninfectious cases of cardiomyopathy. Low Se was found in 6 of 10 chagasic patients with digestive megasyndromes. Thus, the decrease in Se in chagasic patients seems to be a biological marker for Trypanosoma cruzi infection and related to the progression of pathology.