Charge-Conversional Polyionic Complex Micelles-Efficient Nanocarriers for Protein Delivery into Cytoplasm
Charge-Conversional Polyionic Complex Micelles-Efficient Nanocarriers for Protein Delivery into Cytoplasm
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DOI：
10.1002/anie.200900064
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发表时间：
2009-01-01
影响因子：
16.6
通讯作者：
Kataoka, Kazunori
中科院分区：
文献类型：
--
作者：
Lee, Yan;Ishii, Takehiko;Kataoka, Kazunori
快递！开发了含有电荷转换部分柠檬酰胺或顺乌头酰胺的聚离子复合物（PIC）胶束用于细胞质蛋白递送。蛋白质货物上电荷密度的增加有助于PIC胶束的稳定性，而无需交联，并且内体中的电荷转换诱导PIC胶束的解离，从而导致内体的有效释放（见图）。
Special delivery!Polyionic complex (PIC) micelles that contain the charge‐conversional moieties citaconic amide orcis‐aconitic amide were developed for cytoplasmic protein delivery. The increase of the charge density on the protein cargo helped the stability of the PIC micelles without cross‐linking, and the charge‐conversion in endosomes induced the dissociation of the PIC micelles to result in efficient endosomal release (see picture).