Inferring Deleterious-Mutation Parameters in Natural Daphnia Populations.
Inferring Deleterious-Mutation Parameters in Natural Daphnia Populations.
复制标题
自然花花叶种群中推断有害的参数。
DOI：
10.1251/bpo3
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发表时间：
1998-05-14
影响因子：
6.4
通讯作者：
Deng, Hong-Wen
中科院分区：
文献类型：
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作者：
Deng, Hong-Wen
Deng和Lynch提出了从异交群体自交后适应性性状的平均值和遗传方差的变化来表征有害的基因组突变。在周期性孤雌生殖体中可以很容易地获得这样的观察结果。对这两个水蚤种群进行了自交和生命表实验。所有性状的近交衰退和遗传方差的增加都是显著的。采用Deng和Lynch的方法估计基因组突变率（U）、平均显性系数（）、平均选择系数（）和标度基因组突变方差（）。平均而言，、和（^表示估计值）分别为0.84、0.30、0.14和4.6E-4。对于真值， 是下界，并且 上界
Deng and Lynch proposed to characterize deleterious genomic mutations from changes in the mean and genetic variance of fitness traits upon selfing in outcrossing populations. Such observations can be readily acquired in cyclical parthenogens. Selfing and life-table experiments were performed for two such Daphnia populations. A significant inbreeding depression and an increase of genetic variance for all traits analyzed were observed. Deng and Lynch's procedures were employed to estimate the genomic mutation rate (U), mean dominance coefficient (), mean selection coefficient (), and scaled genomic mutational variance (). On average, , , and (^ indicates an estimate) are 0.84, 0.30, 0.14 and 4.6E-4 respectively. For the true values, the and are lower bounds, and and upper bounds.