Plasma ADMA concentrations associate with aerobic fitness in postmenopausal women
Plasma ADMA concentrations associate with aerobic fitness in postmenopausal women
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DOI：
10.1016/j.lfs.2014.05.003
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发表时间：
2014-07-11
期刊：
影响因子：
6.1
通讯作者：
Maeda, Seiji
中科院分区：
文献类型：
--
作者：
Tanahashi, Koichiro;Akazawa, Nobuhiko;Maeda, Seiji
目的：不对称二甲基精氨酸（ADMA）是一氧化氮（NO）合酶的内源性竞争性抑制剂，一氧化氮合酶是一种负责产生NO的酶。老年人和绝经后妇女血浆中ADMA浓度增加。事实上，ADMA水平升高是心血管疾病的危险因素。有氧运动对心血管疾病有好处。然而，ADMA和有氧健身之间的关系是未知的。本研究的目的是确定是否血浆ADMA浓度与有氧健身水平在绝经后women.Main方法：30名健康的绝经后妇女年龄在50-76岁参加了这项研究。我们测量了血浆中ADMA浓度和作为有氧适应性指标的阈氧耗量（VO 2 VT）。以VO 2 VT的中位数为分界线，将受试者分为低有氧适能组（Low fitness）和高有氧适能组（High fitness），结果发现：高适能组的VO 2 VT显著高于低适能组（P < 0.01）。高体适能组血浆ADMA浓度显著低于低体适能组（P < 0.05）。血浆ADMA浓度与VO 2 VT呈负相关（r =-0.532，P < 0.01）。这项研究的结果表明，习惯性有氧运动可能会降低血浆ADMA浓度。(C)2014爱思唯尔公司All rights reserved.
Aims: Asymmetric dimethylarginine (ADMA) is an endogenous competitive inhibitor of nitric oxide (NO) synthase, an enzyme responsible for the generation of NO. Plasma concentrations of ADMA increase in the elderly and in postmenopausal women. In fact, an elevated ADMA level is a risk factor of cardiovascular disease. Aerobic exercise has a beneficial effect on cardiovascular disease. However, the relationship between ADMA and aerobic fitness is unknown. The aim of this study was to determine whether plasma ADMA concentrations correlate with aerobic fitness levels in postmenopausal women.Main methods: Thirty healthy postmenopausal women aged 50-76 years participated in this study. We measured plasma concentrations of ADMA and oxygen consumption at the ventilatory threshold (VO2VT) as an index of aerobic fitness. Subjects were divided into the low aerobic fitness (Low fitness) and high aerobic fitness (High fitness) groups, and the dividing line was set at the median VO2VT value.Key findings: VO2VT was significantly higher in the High fitness group than in the Low fitness group (P < 0.01). The plasma ADMA concentrations in the High fitness group were significantly lower than those in the Low fitness group (P < 0.05). There was a negative correlation between plasma ADMA concentrations and VO2VT (r = -0.532, P < 0.01).Significance: We found that plasma ADMA concentrations were associated with aerobic fitness in postmenopausal women. The results of this study suggest that habitual aerobic exercise may decrease plasma ADMA concentrations. (C) 2014 Elsevier Inc. All rights reserved.